Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat.

Sharma HS, Zimmermann-Meinzingen S, Johanson CE

Annals of the New York Academy of Sciences1 Jun 2010Cited by 71 (Europe PMC)

PMID20633118DOI10.1111/j.1749-6632.2009.05329.xPepBankPUB-20633118

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, Cerebrolysin given 5 min or 1 h after injury significantly reduced BBB tracer leakage versus untreated injury.
In plain wordsIn rats with brain injury, early Cerebrolysin significantly reduced blood-brain barrier tracer leakage compared with untreated injury.
Peptide
Cerebrolysin
Outcome
DecreaseBBB tracer leakage after early treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 or 30 microL · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Intracerebroventricular administration of Cerebrolysin (10 or 30 microL) either 5 min or 1 h after TBI significantly reduced leakage of Evans blue and radioiodine tracers across the BBB and BCSFB,
1 context sentence(design, population, supporting numbers)
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, Cerebrolysin given 5 min or 1 h after injury significantly reduced BCSFB tracer leakage versus untreated injury.
In plain wordsIn rats with brain injury, early Cerebrolysin significantly reduced blood-cerebrospinal fluid barrier tracer leakage compared with untreated injury.
Peptide
Cerebrolysin
Outcome
DecreaseBCSFB tracer leakage after early treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 or 30 microL · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Intracerebroventricular administration of Cerebrolysin (10 or 30 microL) either 5 min or 1 h after TBI significantly reduced leakage of Evans blue and radioiodine tracers across the BBB and BCSFB,
1 context sentence(design, population, supporting numbers)
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311802
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, early Cerebrolysin attenuated cortical and subcortical brain edema versus untreated injury.
In plain wordsIn rats with brain injury, early Cerebrolysin reduced cortical and subcortical brain swelling compared with untreated injury.
Peptide
Cerebrolysin
Outcome
DecreaseBrain edema after early treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 or 30 microL · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
and attenuated brain edema formation/neuronal damage in the cortex as well as underlying subcortical regions.
2 context sentences(design, population, supporting numbers)
Summary · context
Intracerebroventricular administration of Cerebrolysin (10 or 30 microL) either 5 min or 1 h after TBI
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311803
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, early Cerebrolysin attenuated cortical and subcortical neuronal damage versus untreated injury.
In plain wordsIn rats with brain injury, early Cerebrolysin reduced cortical and subcortical nerve cell damage compared with untreated injury.
Peptide
Cerebrolysin
Outcome
DecreaseNeuronal damage after early treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 or 30 microL · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
and attenuated brain edema formation/neuronal damage in the cortex as well as underlying subcortical regions.
2 context sentences(design, population, supporting numbers)
Summary · context
Intracerebroventricular administration of Cerebrolysin (10 or 30 microL) either 5 min or 1 h after TBI
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311804
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, Cerebrolysin improved sensory-motor functions versus untreated injury.
In plain wordsIn rats with brain injury, Cerebrolysin improved sensory-motor functions compared with untreated injury.
Peptide
Cerebrolysin
Outcome
IncreaseSensory-motor function after early treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 or 30 microL · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Cerebrolysin-treated animals also had improved sensory-motor functions.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311805
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, Cerebrolysin given 2 h after injury did not significantly affect BBB tracer leakage.
In plain wordsIn rats with brain injury, Cerebrolysin given 2 h later did not significantly change blood-brain barrier leakage compared with untreated injury.
Peptide
Cerebrolysin
Outcome
No significant changeBBB tracer leakage after delayed treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
However, administration of Cerebrolysin 2 h after TBI did not affect these parameters significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
significantly reduced leakage of Evans blue and radioiodine tracers across the BBB and BCSFB,
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311806
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, Cerebrolysin given 2 h after injury did not significantly affect BCSFB tracer leakage.
In plain wordsIn rats with brain injury, Cerebrolysin given 2 h later did not significantly change blood-cerebrospinal fluid barrier leakage compared with untreated injury.
Peptide
Cerebrolysin
Outcome
No significant changeBCSFB tracer leakage after delayed treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
However, administration of Cerebrolysin 2 h after TBI did not affect these parameters significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
significantly reduced leakage of Evans blue and radioiodine tracers across the BBB and BCSFB,
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311807
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, Cerebrolysin given 2 h after injury did not significantly affect brain edema.
In plain wordsIn rats with brain injury, Cerebrolysin given 2 h later did not significantly change brain swelling compared with untreated injury.
Peptide
Cerebrolysin
Outcome
No significant changeBrain edema after delayed treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
However, administration of Cerebrolysin 2 h after TBI did not affect these parameters significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
and attenuated brain edema formation/neuronal damage in the cortex as well as underlying subcortical regions.
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311808
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, Cerebrolysin given 2 h after injury did not significantly affect neuronal damage.
In plain wordsIn rats with brain injury, Cerebrolysin given 2 h later did not significantly change nerve cell damage compared with untreated injury.
Peptide
Cerebrolysin
Outcome
No significant changeNeuronal damage after delayed treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
However, administration of Cerebrolysin 2 h after TBI did not affect these parameters significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
and attenuated brain edema formation/neuronal damage in the cortex as well as underlying subcortical regions.
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311809
10AnimalAnimal study (in vivo)Efficacy outcome
In rats with traumatic brain injury, Cerebrolysin given 2 h after injury did not significantly affect sensory-motor functions.
In plain wordsIn rats with brain injury, Cerebrolysin given 2 h later did not significantly change sensory-motor functions compared with untreated injury.
Peptide
Cerebrolysin
Outcome
No significant changeSensory-motor function after delayed treatment
Study
ratn: not reported in source
Traumatic brain injury
Comparator
Untreated injured rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
However, administration of Cerebrolysin 2 h after TBI did not affect these parameters significantly.
2 context sentences(design, population, supporting numbers)
Summary · context
Cerebrolysin-treated animals also had improved sensory-motor functions.
Summary · context
In the present investigation, we examined the effects of Cerebrolysin, a mixture of different neurotrophic factors (Ebewe Neuro Pharma, Austria) on the brain pathology and functional outcome in a rat model of TBI.
Report a problemFND-2063311810

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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