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Study · Animal study (in vivo) · rat · 2011

6 results

The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.

Stavchansky VV, Yuzhakov VV, Botsina AY, Skvortsova VI, Bondurko LN, Tsyganova MG, Limborska SA, Myasoedov NF, Dergunova LV

Journal of molecular neuroscience : MN9 Jul 2010Cited by 17 (Europe PMC)

PMID20617398 (opens in a new tab)DOI10.1007/s12031-010-9421-2 (opens in a new tab)PepBankPUB-20617398
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In the normal rat brain, Semax activated the capillary network.

    In plain wordsIn rats, Semax activated the network of small blood vessels in healthy brain tissue.

    Peptide
    Semax
    Outcome
    IncreaseCapillary network activation
    Study

    ratn: not reported in source

    Normal rat brain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In control animals, both peptides activated the capillary network and caused similar morphological changes to neurons and the neuropil regions.
    1 context sentence
    Summary · context
    In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In the normal rat brain, Semax caused morphological changes to neurons and neuropil regions.

    In plain wordsIn rats, Semax changed the structure of nerve cells and the surrounding tissue in healthy brain.

    Peptide
    Semax
    Outcome
    Direction not reportedMorphological changes of neurons and neuropil
    Study

    ratn: not reported in source

    Normal rat brain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In control animals, both peptides activated the capillary network and caused similar morphological changes to neurons and the neuropil regions.
    1 context sentence
    Summary · context
    In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In the rat brain, Semax increased proliferation of neuroglia.

    In plain wordsIn rats, Semax increased the growth of support cells in the brain.

    Peptide
    Semax
    Outcome
    IncreaseNeuroglia proliferation
    Study

    ratn: not reported in source

    Normal rat brain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We show here for the first time at the histological level that Semax and PGP increased proliferation of the neuroglia, blood vessel endothelium, and progenitor cells in the subventricular zone.
    1 context sentence
    Summary · context
    In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In the rat brain, Semax increased proliferation of blood vessel endothelium.

    In plain wordsIn rats, Semax increased the growth of cells lining brain blood vessels.

    Peptide
    Semax
    Outcome
    IncreaseBlood vessel endothelium proliferation
    Study

    ratn: not reported in source

    Normal rat brain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We show here for the first time at the histological level that Semax and PGP increased proliferation of the neuroglia, blood vessel endothelium, and progenitor cells in the subventricular zone.
    1 context sentence
    Summary · context
    In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In the rat brain, Semax increased proliferation of progenitor cells in the subventricular zone.

    In plain wordsIn rats, Semax increased the growth of progenitor cells in a brain region that makes new cells.

    Peptide
    Semax
    Outcome
    IncreaseProgenitor cell proliferation in the subventricular zone
    Study

    ratn: not reported in source

    Normal rat brain
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We show here for the first time at the histological level that Semax and PGP increased proliferation of the neuroglia, blood vessel endothelium, and progenitor cells in the subventricular zone.
    1 context sentence
    Summary · context
    In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with incomplete global brain ischemia, Semax reduced the manifestation of ischemic damage to nervous tissue; PGP did not.

    In plain wordsIn rats with reduced brain blood flow, Semax lessened damage to brain tissue, but the PGP peptide did not.

    Peptide
    Semax
    Outcome
    DecreaseIschemic damage to nervous tissue
    Study

    ratn: not reported in source

    Incomplete global brain ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In these experimental conditions, only Semax abated the manifestation of ischemic damage to the nervous tissue.
    1 context sentence
    Summary · context
    In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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