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Study · Non-randomized trial · n = 23 · 2010

2 results

Effect of growth hormone replacement therapy on cognition after traumatic brain injury.

High WM Jr, Briones-Galang M, Clark JA, Gilkison C, Mossberg KA, Zgaljardic DJ, Masel BE, Urban RJ

Journal of neurotrauma1 Sept 2010Cited by 117 (Europe PMC)

PMID20578825 (opens in a new tab)PMCIDPMC2966848 (opens in a new tab)DOI10.1089/neu.2009.1253 (opens in a new tab)PepBankPUB-20578825
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialSafety outcome

    In participants with chronic traumatic brain injury, GH replacement produced no untoward treatment side effects.

    In plain wordsIn participants with chronic brain injury, GH replacement produced no untoward treatment side effects.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableUntoward side effects
    Study

    n = 23

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · 1 yearAs given in this study (human).

    Source sentences

    Summary
    All subjects completed the study with no untoward side effects from treatment.
    1 context sentence
    Summary · context
    Forty-two subjects were found to have either GHD or GH insufficiency (GHI), of which 23 agreed to be randomized to either a year of GH replacement or placebo.
  2. 02HumanNon-randomized trialEfficacy outcome

    In participants with chronic traumatic brain injury, improvement occurred on finger tapping, information processing, verbal learning, and executive functioning tests.

    In plain wordsIn participants with chronic brain injury, finger tapping, processing speed, verbal learning, and executive functioning tests improved.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseNeuropsychological test performance
    Study

    n = 23

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · 1 yearAs given in this study (human).

    Source sentences

    Summary
    Improvement was seen on the following tests: Dominant Hand Finger Tapping Test, Wechsler Adult Intelligence Scale III-Information Processing Speed Index, California Verbal Learning Test II, and the Wisconsin Card Sorting Test (executive functioning).
    1 context sentence
    Summary · context
    Forty-two subjects were found to have either GHD or GH insufficiency (GHI), of which 23 agreed to be randomized to either a year of GH replacement or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 2NCT04121780

Growth Hormone Replacement Therapy for Retried Professional Football Players

Center for Neurological Studiesn = 428 Oct 2019 to est. Sept 2026

TBI (Traumatic Brain Injury) · Concussion, Brain · Sport Injury · Anterior Pituitary Hyposecretion Syndrome · Hypopituitarism · Growth Hormone Deficiency

Trial pageClinicalTrials.govUpdated 8 Feb 2023

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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