Preferential expression of IGF-1Ec (MGF) transcript in cancerous tissues of human prostate: evidence for a novel and autonomous growth factor activity of MGF E peptide in human prostate cancer cells.

Armakolas A, Philippou A, Panteleakou Z, Nezos A, Sourla A, Petraki C, Koutsilieris M

The Prostate1 Aug 2010Cited by 40 (Europe PMC)

PMID20564425DOI10.1002/pros.21158PepBankPUB-20564425

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In human prostate cancer cell lines, exogenous synthetic MGF E peptide stimulated cell growth.
In plain wordsIn lab tests, MGF E peptide made human prostate cancer cells grow more.
Peptide
MGF / PEG-MGF
Outcome
IncreaseProstate cancer cell proliferation
Study
humann: not reported in source
Human prostate cancer cell lines (PC-3, LNCaP)
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Exogenous administration of a synthetic MGF E peptide stimulated the PCa cell growth
1 context sentence(design, population, supporting numbers)
Summary · context
We used immunohistochemistry, RT-PCR, and Western analysis to show the expression status of MGF in prostate tissue and human prostate cell lines (HPrEC, PC-3, and LNCaP) and we studied the exogenous administration of the MGF peptide E on cellular proliferation using trypan blue and MTT assays, befor…
Report a problemFND-2056442504
02LabIn vitro (cells)Mechanism
In human prostate cancer cell lines, exogenous synthetic MGF E peptide activated ERK1/2 phosphorylation.
In plain wordsIn lab tests, MGF E peptide switched on the ERK1/2 signal in human prostate cancer cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseERK1/2 phosphorylation
Study
humann: not reported in source
Human prostate cancer cell lines (PC-3, LNCaP)
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Exogenous administration of a synthetic MGF E peptide stimulated the PCa cell growth and activated ERK1/2 phosphorylation
1 context sentence(design, population, supporting numbers)
Summary · context
We used immunohistochemistry, RT-PCR, and Western analysis to show the expression status of MGF in prostate tissue and human prostate cell lines (HPrEC, PC-3, and LNCaP) and we studied the exogenous administration of the MGF peptide E on cellular proliferation using trypan blue and MTT assays, befor…
Report a problemFND-2056442505
03LabIn vitro (cells)Mechanism
In human prostate cancer cell lines, exogenous synthetic MGF E peptide did not affect Akt phosphorylation.
In plain wordsIn lab tests, MGF E peptide did not change the Akt signal in human prostate cancer cells.
Peptide
MGF / PEG-MGF
Outcome
No significant changeAkt phosphorylation
Study
humann: not reported in source
Human prostate cancer cell lines (PC-3, LNCaP)
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
without affecting Akt phosphorylation.
1 context sentence(design, population, supporting numbers)
Summary · context
We used immunohistochemistry, RT-PCR, and Western analysis to show the expression status of MGF in prostate tissue and human prostate cell lines (HPrEC, PC-3, and LNCaP) and we studied the exogenous administration of the MGF peptide E on cellular proliferation using trypan blue and MTT assays, befor…
Report a problemFND-2056442506
04LabIn vitro (cells)Mechanism
In prostate cancer cells, silencing IGF-1R or the insulin receptor did not affect the mitogenic activity of MGF E peptide.
In plain wordsIn lab tests, blocking IGF-1R or the insulin receptor did not stop MGF E peptide from making prostate cancer cells grow.
Peptide
MGF / PEG-MGF
Outcome
No significant changeMitogenic activity of MGF E peptide after IGF-1R or insulin receptor silencing
Study
humann: not reported in source
Human prostate cancer cells with IGF-1R or IR siRNA
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
IGF-1R or insulin receptor (IR) silencing did not affect the mitogenic activity and intracellular signaling of the MGF E peptide in these PCa cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We used immunohistochemistry, RT-PCR, and Western analysis to show the expression status of MGF in prostate tissue and human prostate cell lines (HPrEC, PC-3, and LNCaP) and we studied the exogenous administration of the MGF peptide E on cellular proliferation using trypan blue and MTT assays, befor…
Report a problemFND-2056442507
05LabIn vitro (cells)Mechanism
In prostate cancer cells, silencing IGF-1R or the insulin receptor did not affect the intracellular signaling of MGF E peptide.
In plain wordsIn lab tests, blocking IGF-1R or the insulin receptor did not change the cell signals that MGF E peptide caused.
Peptide
MGF / PEG-MGF
Outcome
No significant changeIntracellular signaling of MGF E peptide after IGF-1R or insulin receptor silencing
Study
humann: not reported in source
Human prostate cancer cells with IGF-1R or IR siRNA
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
IGF-1R or insulin receptor (IR) silencing did not affect the mitogenic activity and intracellular signaling of the MGF E peptide in these PCa cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We used immunohistochemistry, RT-PCR, and Western analysis to show the expression status of MGF in prostate tissue and human prostate cell lines (HPrEC, PC-3, and LNCaP) and we studied the exogenous administration of the MGF peptide E on cellular proliferation using trypan blue and MTT assays, befor…
Report a problemFND-2056442508

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

06HumanEndogenous levelObservational studyOther
In human prostate tissue, natural MGF expression was higher in prostate cancer and prostatic intraepithelial neoplasia than in normal prostate tissue.
In plain wordsIn human prostate samples, the body's own MGF was higher in prostate cancer and pre-cancer tissue than in normal tissue.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMGF expression in prostate cancer tissue
Study
n: not reported in source
Comparator
Normal prostate tissue
Outcome group
Tumor growth · Cancer
Source sentences
Summary
MGF expression was remarkably higher in PCa and prostatic intraepithelial neoplasia (PIN) than normal prostate tissues
1 context sentence(design, population, supporting numbers)
Summary · context
We used immunohistochemistry, RT-PCR, and Western analysis to show the expression status of MGF in prostate tissue and human prostate cell lines (HPrEC, PC-3, and LNCaP) and we studied the exogenous administration of the MGF peptide E on cellular proliferation using trypan blue and MTT assays, befor…
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2056442501
07LabEndogenous levelIn vitro (cells)Other
Natural MGF was overexpressed in human PC-3 and LNCaP prostate cancer cells.
In plain wordsIn human prostate cancer cell lines, the cells made more of the body's own MGF.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMGF expression in prostate cancer cell lines
Study
humann: not reported in source
PC-3 and LNCaP prostate cancer cell lines
Outcome group
Tumor growth · Cancer
Source sentences
Summary
We documented that MGF is overexpressed in human prostate cancer (PCa) tissues and in human PC-3 and LNCaP cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We used immunohistochemistry, RT-PCR, and Western analysis to show the expression status of MGF in prostate tissue and human prostate cell lines (HPrEC, PC-3, and LNCaP) and we studied the exogenous administration of the MGF peptide E on cellular proliferation using trypan blue and MTT assays, befor…
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2056442502
08LabEndogenous levelIn vitro (cells)Other
Normal human prostate epithelial cells (HPrEC) did not express MGF.
In plain wordsNormal human prostate cells did not make the body's own MGF.
Peptide
MGF / PEG-MGF
Outcome
Not applicableMGF expression in normal prostate epithelial cells
Study
humann: not reported in source
HPrEC normal prostate epithelial cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
while the normal prostate epithelial cells (HPrEC) did not express MGF.
1 context sentence(design, population, supporting numbers)
Summary · context
We used immunohistochemistry, RT-PCR, and Western analysis to show the expression status of MGF in prostate tissue and human prostate cell lines (HPrEC, PC-3, and LNCaP) and we studied the exogenous administration of the MGF peptide E on cellular proliferation using trypan blue and MTT assays, befor…
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2056442503

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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