Skip to content

Study · In vitro (cells) · 2010

4 results

Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor.

Gravati M, Busnelli M, Bulgheroni E, Reversi A, Spaiardi P, Parenti M, Toselli M, Chini B

Journal of neurochemistry14 Jun 2010Cited by 69 (Europe PMC)

PMID20557424 (opens in a new tab)DOI10.1111/j.1471-4159.2010.06861.x (opens in a new tab)PepBankPUB-20557424
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In GN11 olfactory neuronal cells, oxytocin receptor stimulation by oxytocin led to accumulation of inositol phosphates.

    In plain wordsIn lab-grown nerve cells, oxytocin triggered a build-up of inositol phosphates, a cell-signalling molecule.

    Peptide
    Oxytocin
    Outcome
    IncreaseInositol phosphate accumulation
    Study

    n: not reported in source

    GN11 immortalized GnRH-positive olfactory neuronal cell line
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whose stimulation by oxytocin led to the accumulation of inositol phosphates
    1 context sentence
    Summary · context
    As an experimental model, we used the immortalized gonadotropin-releasing hormone-positive GN11 cell line displaying the features of immature, migrating olfactory neurons.
  2. 02LabIn vitro (cells)Efficacy outcome

    In GN11 olfactory neuronal cells, oxytocin receptor stimulation by oxytocin led to inhibition of cell proliferation.

    In plain wordsIn lab-grown nerve cells, oxytocin slowed cell multiplication.

    Peptide
    Oxytocin
    Outcome
    DecreaseCell proliferation
    Study

    n: not reported in source

    GN11 immortalized GnRH-positive olfactory neuronal cell line
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whose stimulation by oxytocin led to the accumulation of inositol phosphates and to the inhibition of cell proliferation
    1 context sentence
    Summary · context
    As an experimental model, we used the immortalized gonadotropin-releasing hormone-positive GN11 cell line displaying the features of immature, migrating olfactory neurons.
  3. 03LabIn vitro (cells)Mechanism

    In GN11 cells, whole-cell patch-clamp recordings showed that inward rectifier channel subtypes responded to oxytocin, which either inhibited or stimulated IR conductances.

    In plain wordsIn lab-grown nerve cells, oxytocin either reduced or raised the current through certain potassium channels.

    Peptide
    Oxytocin
    Outcome
    MixedInward rectifier K+ channel responsiveness to oxytocin
    Study

    n: not reported in source

    GN11 immortalized GnRH-positive olfactory neuronal cell line
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, electrophysiological and pharmacological inspections using whole-cell patch-clamp recordings evidenced that in GN11 cells, IR channel subtypes are responsive to oxytocin.
    2 context sentences
    Summary · context
    In particular, we found that: (i) peptide activation of receptor either inhibited or stimulated IR conductances
    Summary · context
    As an experimental model, we used the immortalized gonadotropin-releasing hormone-positive GN11 cell line displaying the features of immature, migrating olfactory neurons.
  4. 04LabIn vitro (cells)Mechanism

    In GN11 cells, inhibition of IR current was mediated by a pertussis toxin-resistant G protein presumably of the Gq/11 subtype and by phospholipase C, while activation worked via a pertussis toxin-sensitive Gi/o protein.

    In plain wordsIn lab-grown nerve cells, oxytocin's opposite effects on potassium currents ran through two different G protein signalling routes.

    Peptide
    Oxytocin
    Outcome
    Not applicableG protein coupling of the oxytocin receptor for IR current modulation
    Study

    n: not reported in source

    GN11 immortalized GnRH-positive olfactory neuronal cell line
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (ii) IR current inhibition was mediated by a pertussis toxin-resistant G protein presumably of the G(q/11) subtype, and by phospholipase C, whereas IR current activation was achieved via receptor coupling to a pertussis toxin-sensitive G(i/o) protein.
    1 context sentence
    Summary · context
    As an experimental model, we used the immortalized gonadotropin-releasing hormone-positive GN11 cell line displaying the features of immature, migrating olfactory neurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.