In recreational stimulant users, tesofensine did not differ significantly from placebo on the reported subjective measures.
In plain wordsIn recreational stimulant users, tesofensine did not differ significantly from placebo on the reported subjective measures.
- Peptide
- Tesofensine
- Outcome
- No significant changeSubjective abuse-related measures
- Study
n = 52
- Comparator
- Placebo
- Outcome group
- Addiction, withdrawal and alcohol intake · Nervous system and cognition
- Studied dose
- Dose not stated · 48 hours after a single doseAs given in this study (human).
Source sentences
The effects of tesofensine were not significantly different from those of placebo and were lower than those of D-amphetamine 30 mg on all primary and most secondary measures.
2 context sentences(design, population, supporting numbers)
The study results show that the effects of D-amphetamine were significantly greater than those of placebo on all primary and secondary subjective measures.
It was designed as a single-dose, randomized, double-blind, crossover study involving tesofensine vs. placebo, D-amphetamine (positive control for dopaminergic/stimulant effects), bupropion, and atomoxetine (negative/unscheduled controls) in recreational stimulant users (N = 52).