[Antihypoxic and antiamnesic effects of mexidol and semax].

In mice, a single dose of semax at 0.05 mg/kg only produced an antihypoxic effect in the altitude chamber and hermetic chamber tests.

In plain wordsIn mice, a single semax dose of 0.05 mg/kg only gave protection against low oxygen in two chamber tests.

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In mice, a 6-day preventive course of semax at 0.1 mg/kg per day gave a significant antihypoxic effect in acute hypobaric hypoxia, where a single dose was ineffective.

In plain wordsIn mice, six days of semax at 0.1 mg/kg per day protected against low oxygen, where one dose did not.

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In mice, a single dose of semax was not effective in models of acute hemic and histotoxic hypoxia.

In plain wordsIn mice, one dose of semax did not protect in two other models of low oxygen.

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In mice, semax had marked antiamnesic effects on various models of amnesia, comparable with piracetam and oxyracetam.

In plain wordsIn mice, semax reduced memory loss in several models, to a degree similar to piracetam and oxyracetam.

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In mice, the antiamnesic effects of semax did not extend to amnesia induced by maximal electroshock.

In plain wordsIn mice, semax did not reduce memory loss caused by strong electric shock.

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In mice, semax showed a bell-shaped reversible dose-effect relationship.

In plain wordsIn mice, semax effects followed a bell-shaped dose curve, so more drug was not always better.

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In rat hippocampal slices, semax inhibited the ortho- and antidromic population response spikes of CA1 pyramidal neurons.

In plain wordsIn lab tests on rat brain slices, semax reduced the electrical response spikes of CA1 nerve cells.

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In rat brain mitochondria, semax, in contrast to mexidol, did not increase oxygen consumption.

In plain wordsIn lab tests on rat brain mitochondria, semax did not raise oxygen use, unlike mexidol.

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