Dose-dependent increase in intratesticular testosterone by very low-dose human chorionic gonadotropin in normal men with experimental gonadotropin deficiency.

Roth MY, Page ST, Lin K, Anawalt BD, Matsumoto AM, Snyder CN, Marck BT, Bremner WJ, Amory JK

The Journal of clinical endocrinology and metabolism19 May 2010Cited by 49 (Europe PMC)

PMID20484472PMCIDPMC2913032DOI10.1210/jc.2010-0360PepBankPUB-20484472

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanRandomized controlled trialEfficacy outcome
In normal men with experimental gonadotropin deficiency, IT-T rose dose-dependently from 77 nmol/liter with 0 IU to 923 nmol/liter with 125 IU hCG.
In plain wordsIn men with experimental gonadotropin deficiency, testicular testosterone was higher with 125 IU hCG than with 0 IU.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseIntratesticular testosterone dose response
Study
n: not reported in source
Comparator
0 IU hCG
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
125 IU every other day · sc · 10 dAs given in this study (human).
Measurements
Intratesticular testosterone concentration
77 nmol/liter
0 IU hCG group, after 10 d
Reported parenthetical interval for intratesticular testosterone concentration
40 to 122 nmol/liter
0 IU hCG group, after 10 d
Intratesticular testosterone concentration
923 nmol/liter
125 IU hCG group, after 10 d
Reported parenthetical interval for intratesticular testosterone concentration
894 to 1017 nmol/liter
125 IU hCG group, after 10 d
p value for dose-dependent intratesticular testosterone increase
< 0.001 p value
Very low-dose hCG dose response, reported 0- and 125-IU groups
Source sentences
Summary
IT-T concentrations increased in a dose-dependent manner with very low-dosage hCG administration from 77 nmol/liter (40, 122 nmol/liter) to 923 nmol/liter (894, 1017 nmol/liter) in the 0- and 125-IU groups, respectively (P<0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
We induced experimental gonadotropin deficiency in 37 normal men with the GnRH antagonist acyline and randomized them to receive one of four low doses of hCG: 0, 15, 60, or 125 IU sc every other day or 7.5 g daily testosterone gel for 10 d.
Report a problemFND-2048447201
02HumanRandomized controlled trialMechanism
In normal men with experimental gonadotropin deficiency, serum hCG correlated significantly with intratesticular testosterone.
In plain wordsIn men with experimental gonadotropin deficiency, blood hCG levels correlated with testosterone inside the testes.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Direction not reportedSerum hCG association with IT-T
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0, 15, 60, or 125 IU every other day · sc · 10 dAs given in this study (human).
Measurements
p value for serum hCG association with intratesticular testosterone
< 0.01 p value
Serum hCG versus intratesticular testosterone
Source sentences
Summary
Moreover, serum hCG was significantly correlated with both IT-T and serum testosterone (P<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
We induced experimental gonadotropin deficiency in 37 normal men with the GnRH antagonist acyline and randomized them to receive one of four low doses of hCG: 0, 15, 60, or 125 IU sc every other day or 7.5 g daily testosterone gel for 10 d.
Report a problemFND-2048447202
03HumanRandomized controlled trialMechanism
In normal men with experimental gonadotropin deficiency, serum hCG correlated significantly with serum testosterone.
In plain wordsIn men with experimental gonadotropin deficiency, blood hCG levels correlated with blood testosterone levels.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Direction not reportedSerum hCG association with serum testosterone
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0, 15, 60, or 125 IU every other day · sc · 10 dAs given in this study (human).
Measurements
P value for serum hCG correlation with serum testosterone
< 0.01 P value
Serum hCG versus serum testosterone
Source sentences
Summary
Moreover, serum hCG was significantly correlated with both IT-T and serum testosterone (P<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
We induced experimental gonadotropin deficiency in 37 normal men with the GnRH antagonist acyline and randomized them to receive one of four low doses of hCG: 0, 15, 60, or 125 IU sc every other day or 7.5 g daily testosterone gel for 10 d.
Report a problemFND-2048447203

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials2

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

2 trials · 1 completed · 1 stopped early · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

WithdrawnPhase 2NCT02147964

ITT-5 Mechanisms of Spermatogenesis in Man

University of Washingtonn = 0est. Jun 2019 to est. Dec 2026

Gonadotropin Deficiency

Trial page ClinicalTrials.govUpdated 18 Dec 2019

CompletedPhase 1/2Results postedNCT00839319

HOP-3 Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone

University of Washingtonn = 59Mar 2009 to Nov 2010

Healthy Males

Trial page ClinicalTrials.govUpdated 11 Jan 2016

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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