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Study · Randomized controlled trial · n = 17 · 2010

2 results

Intranasal oxytocin increases fathers' observed responsiveness during play with their children: a double-blind within-subject experiment.

Naber F, van Ijzendoorn MH, Deschamps P, van Engeland H, Bakermans-Kranenburg MJ

Psychoneuroendocrinology8 May 2010Cited by 146 (Europe PMC)

PMID20457491 (opens in a new tab)DOI10.1016/j.psyneuen.2010.04.007 (opens in a new tab)PepBankPUB-20457491
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In fathers playing with their toddlers, intranasal oxytocin increased stimulation of the child's exploration compared with placebo.

    In plain wordsIn fathers playing with toddlers, intranasal oxytocin led to more encouragement of the child's exploration than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseFathers' stimulation of child's exploration
    Study

    n = 17

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In the oxytocin condition fathers were more stimulating of their child's exploration than in the placebo condition
    2 context sentences
    Summary · context
    Here the first double-blind, placebo-controlled, within-subject experiment with intranasal oxytocin administration is presented.
    Summary · context
    Subjects were 17 fathers with their toddler, observed in two play sessions of 15 min each with an intervening period of 1 week.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In fathers playing with their toddlers, intranasal oxytocin was associated with only a tendency toward less hostility than placebo.

    In plain wordsIn fathers playing with toddlers, oxytocin showed only a trend toward less hostility compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeFathers' hostility
    Study

    n = 17

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    and they tended to show less hostility.
    2 context sentences
    Summary · context
    Here the first double-blind, placebo-controlled, within-subject experiment with intranasal oxytocin administration is presented.
    Summary · context
    Subjects were 17 fathers with their toddler, observed in two play sessions of 15 min each with an intervening period of 1 week.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

WithdrawnPhase 1NCT01912378

Triadic Interactions of Families With Autism and Oxytocin

University of California, San Franciscon = 0Aug 2013 to May 2015

Autism Disorder

Trial pageClinicalTrials.govUpdated 16 Jan 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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