Treatment with neuropeptides attenuates c-fos expression in a mouse model of fetal alcohol syndrome.

Incerti M, Vink J, Roberson R, Abebe D, Spong CY

American journal of perinatology4 May 2010Cited by 3 (Europe PMC)

PMID20446212DOI10.1055/s-0030-1253558PepBankPUB-20446212

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Davunetide.

01AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In prenatal alcohol-exposed mice, D-NAP plus D-SAL restored hippocampal C-FOS down-regulation compared with placebo.
In plain wordsIn mice exposed to alcohol before birth, D-NAP plus D-SAL restored reduced hippocampal C-FOS expression compared with placebo.
Peptide
Davunetide
Outcome
DecreaseHippocampal C-FOS expression
Study
mousen = 10
Prenatal alcohol-exposed male mice
Comparator
Placebo-treated alcohol-exposed mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Adult treatment with NAP + SAL restored the down-regulation of C-FOS in the hippocampus after prenatal alcohol exposure ( P < 0.05), but not in the cerebellum.
2 context sentences(design, population, supporting numbers)
Summary · context
C57Bl6/J mice were treated with alcohol (0.03 mL/g) or placebo on gestational day 8.
Summary · context
On postnatal day 40, in utero alcohol-exposed males were treated via gavage with 40 μg D-NAP and 40 μg D-SAL ( N = 6) or placebo ( N = 4); controls were gavaged with placebo daily ( N = 12).
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2044621201
02AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism
In prenatal alcohol-exposed mice, D-NAP plus D-SAL did not restore cerebellar C-FOS down-regulation compared with placebo.
In plain wordsIn mice exposed to alcohol before birth, D-NAP plus D-SAL did not restore reduced cerebellar C-FOS expression compared with placebo.
Peptide
Davunetide
Outcome
No significant changeCerebellar C-FOS expression
Study
mousen = 10
Prenatal alcohol-exposed male mice
Comparator
Placebo-treated alcohol-exposed mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Adult treatment with NAP + SAL restored the down-regulation of C-FOS in the hippocampus after prenatal alcohol exposure ( P < 0.05), but not in the cerebellum.
2 context sentences(design, population, supporting numbers)
Summary · context
C57Bl6/J mice were treated with alcohol (0.03 mL/g) or placebo on gestational day 8.
Summary · context
On postnatal day 40, in utero alcohol-exposed males were treated via gavage with 40 μg D-NAP and 40 μg D-SAL ( N = 6) or placebo ( N = 4); controls were gavaged with placebo daily ( N = 12).
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.
Report a problemFND-2044621202

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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