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Study · Animal study (in vivo) · siberian hamster · 2010

5 results

Central melanocortin stimulation increases phosphorylated perilipin A and hormone-sensitive lipase in adipose tissues.

Shrestha YB, Vaughan CH, Smith BJ Jr, Song CK, Baro DJ, Bartness TJ

American journal of physiology. Regulatory, integrative and comparative physiology21 Apr 2010Cited by 34 (Europe PMC)

PMID20410474 (opens in a new tab)PMCIDPMC2904151 (opens in a new tab)DOI10.1152/ajpregu.00535.2009 (opens in a new tab)PepBankPUB-20410474
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Siberian hamsters, a single third-ventricle injection of MTII increased circulating glycerol at 0.5 and 1.0 h after injection.

    In plain wordsIn hamsters, a brain injection of melanotan II raised blood glycerol, a sign of fat breakdown, at 0.5 and 1.0 hours.

    Peptide
    Melanotan II
    Outcome
    IncreaseCirculating glycerol
    Study

    Siberian hamstern: not reported in source

    Male Siberian hamsters
    Comparator
    Saline
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (third ventricle) · single injectionAs given in this study (Siberian hamster).

    Source sentences

    Summary
    MTII increased circulating glycerol concentrations at 0.5 and 1.0 h
    1 context sentence
    Summary · context
    Male Siberian hamsters received a single 3rd ventricular injection of MTII or saline.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Siberian hamsters, a single third-ventricle injection of MTII increased circulating free fatty acid concentrations at 1.0 and 2.0 h.

    In plain wordsIn hamsters, a brain injection of melanotan II raised blood free fatty acids, a sign of fat breakdown, at 1.0 and 2.0 hours.

    Peptide
    Melanotan II
    Outcome
    IncreaseCirculating free fatty acids
    Study

    Siberian hamstern: not reported in source

    Male Siberian hamsters
    Comparator
    Saline
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (third ventricle) · single injectionAs given in this study (Siberian hamster).

    Source sentences

    Summary
    whereas free fatty acid concentrations were increased at 1.0 and 2.0 h.
    1 context sentence
    Summary · context
    Male Siberian hamsters received a single 3rd ventricular injection of MTII or saline.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In Siberian hamsters, MTII increased phosphorylated perilipin A and hormone-sensitive lipase only in fat pads that previously showed MTII-induced increases in norepinephrine turnover.

    In plain wordsIn hamsters, melanotan II raised two fat-breakdown markers only in the fat pads where it had earlier raised norepinephrine turnover.

    Peptide
    Melanotan II
    Outcome
    Increasep-perilipin A and hormone-sensitive lipase in fat pads with raised NE turnover
    Study

    Siberian hamstern: not reported in source

    Male Siberian hamsters
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (third ventricle) · single injectionAs given in this study (Siberian hamster).

    Source sentences

    Summary
    Western blot analysis showed that MTII specifically increased p-perilipin A and hormone-sensitive lipase only in fat pads that previously had MTII-induced increases in NETO.
    1 context sentence
    Summary · context
    Male Siberian hamsters received a single 3rd ventricular injection of MTII or saline.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In Siberian hamsters, MTII increased phosphorylation of perilipin A in inguinal white fat at all time points and in interscapular brown fat at 0.5 h.

    In plain wordsIn hamsters, melanotan II raised a fat-breakdown marker in inguinal white fat and, at 0.5 hours, in brown fat.

    Peptide
    Melanotan II
    Outcome
    Increasep-perilipin A in IWAT and IBAT
    Study

    Siberian hamstern: not reported in source

    Male Siberian hamsters
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (third ventricle) · single injectionAs given in this study (Siberian hamster).

    Source sentences

    Summary
    Phosphorylation increased in IWAT at all time points and IBAT at 0.5 h
    1 context sentence
    Summary · context
    Male Siberian hamsters received a single 3rd ventricular injection of MTII or saline.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In Siberian hamsters, MTII did not increase phosphorylation in retroperitoneal or epididymal white fat at any time point.

    In plain wordsIn hamsters, melanotan II did not raise the fat-breakdown marker in retroperitoneal or epididymal fat at any time point.

    Peptide
    Melanotan II
    Outcome
    No significant changep-perilipin A in RWAT and EWAT
    Study

    Siberian hamstern: not reported in source

    Male Siberian hamsters
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (third ventricle) · single injectionAs given in this study (Siberian hamster).

    Source sentences

    Summary
    but not RWAT or EWAT at any time point.
    2 context sentences
    Summary · context
    Western blot analysis showed that MTII specifically increased p-perilipin A and hormone-sensitive lipase only in fat pads that previously had MTII-induced increases in NETO.
    Summary · context
    Male Siberian hamsters received a single 3rd ventricular injection of MTII or saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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