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Study · Not a test of the peptide alone · 2010

2 results

Production of thymosin alpha1 via non-enzymatic acetylation of the recombinant precursor.

Esipov RS, Stepanenko VN, Beyrakhova KA, Muravjeva TI, Miroshnikov AI

Biotechnology and applied biochemistry19 May 2010Cited by 8 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneOther designOther

    Selective N-terminal acetylation of recombinant desacetylthymosin alpha1 with acetic anhydride gave a yield of 62%.

    In plain wordsIn lab production, the acetylation step of thymosin alpha‑1 gave a 62% yield.

    Outcome
    Not applicableYield of N-terminal acetylation
    Study

    n: not reported in source

    E. coli expression and chemical acetylation
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Measurements

    Acetylation yield
    62%
    N-terminal acetylation

    Source sentences

    Summary
    Acetic anhydride was used for selective N-terminal acetylation of the obtained peptide (yield=62%).

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneOther designOther

    The optimized process gave recombinant thymosin alpha1 at an average of 29 mg per litre of bacterial culture.

    In plain wordsIn lab production, the process gave about 29 mg of thymosin alpha‑1 per litre of bacterial culture.

    Outcome
    Not applicableYield of recombinant thymosin alpha1 per litre of culture
    Study

    n: not reported in source

    E. coli expression and chemical acetylation
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Measurements

    Yield
    29 mg/litre
    bacterial culture

    Source sentences

    Summary
    Each stage of the process was optimized to increase the yield of the target peptide, which averaged 29 mg/litre of bacterial culture.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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