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Study · Animal study (in vivo) · rat · 2010

3 results

[Influence of Semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action].

Levitskaia NG, Vilenskiĭ DA, Sebentsova EA, Anreeva LA, Kamenskiĭ AA, Miasoedov NF

Izvestiia Akademii nauk. Seriia biologicheskaia1 Mar 2010Cited by 1 (Europe PMC)

PMID20387390 (opens in a new tab)DOI10.1134/s1062359010020147 (opens in a new tab)PepBankPUB-20387390
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In white rats in the normal state, intranasal semax did not influence the emotional state.

    In plain wordsIn rats with normal behavior, semax did not change anxiety or depression-like behavior.

    Peptide
    Semax
    Outcome
    No significant changeEmotional state in the normal state
    Study

    ratn: not reported in source

    Elevated plus-maze and forced swimming tests, with and without CCK-4
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    50 and 500 microg/kg · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Semax administration did not influence the emotional state of animals in the normal state.
    2 context sentences
    Summary · context
    The effects of the adrenocorticotropic hormone (ACTH(4-10)) analog, Semax (MEHFPGP), on the level of anxiety and depression in white rats have been studied in the normal state and against the background of cholecystokinin-tetrapeptide (CCK-4) action.
    Summary · context
    The level of anxiety was estimated in the elevated plus-maze test, and the degree of depression, in the forced swimming test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In white rats with anxiety raised by CCK-4, intranasal semax normalized the disturbed behavior, which shows an anxiolytic effect.

    In plain wordsIn rats made anxious with CCK-4, semax brought behavior back toward normal.

    Peptide
    Semax
    Outcome
    DecreaseAnxiety after CCK-4 (elevated plus-maze)
    Study

    ratn: not reported in source

    Elevated plus-maze and forced swimming tests, with and without CCK-4
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    50 and 500 microg/kg · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Semax normalized the animal behavior disturbed by the CCK-4 administration, which attests to its anxiolytic and antidepressant effects at elevated levels of anxiety and depression.
    2 context sentences
    Summary · context
    The effects of the adrenocorticotropic hormone (ACTH(4-10)) analog, Semax (MEHFPGP), on the level of anxiety and depression in white rats have been studied in the normal state and against the background of cholecystokinin-tetrapeptide (CCK-4) action.
    Summary · context
    The level of anxiety was estimated in the elevated plus-maze test, and the degree of depression, in the forced swimming test.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In white rats with depression raised by CCK-4, intranasal semax normalized the disturbed behavior, which shows an antidepressant effect.

    In plain wordsIn rats made depressed-like with CCK-4, semax brought behavior back toward normal.

    Peptide
    Semax
    Outcome
    DecreaseDepression after CCK-4 (forced swimming test)
    Study

    ratn: not reported in source

    Elevated plus-maze and forced swimming tests, with and without CCK-4
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    50 and 500 microg/kg · intranasalAs given in this study (rat).

    Source sentences

    Summary
    Semax normalized the animal behavior disturbed by the CCK-4 administration, which attests to its anxiolytic and antidepressant effects at elevated levels of anxiety and depression.
    2 context sentences
    Summary · context
    The effects of the adrenocorticotropic hormone (ACTH(4-10)) analog, Semax (MEHFPGP), on the level of anxiety and depression in white rats have been studied in the normal state and against the background of cholecystokinin-tetrapeptide (CCK-4) action.
    Summary · context
    The level of anxiety was estimated in the elevated plus-maze test, and the degree of depression, in the forced swimming test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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