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Study · Ex vivo tissue · 2010

3 results

Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells.

Kondratenko RV, Derevyagin VI, Skrebitsky VG

Neuroscience letters9 Apr 2010Cited by 4 (Europe PMC)

PMID20382202 (opens in a new tab)DOI10.1016/j.neulet.2010.04.005 (opens in a new tab)PepBankPUB-20382202
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In hippocampal CA1 pyramidal cells, Noopept significantly increased the frequency of spike-dependent spontaneous inhibitory postsynaptic currents.

    In plain wordsIn lab tests, Noopept increased the frequency of spike-dependent inhibitory signals in hippocampal cells.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseSpontaneous IPSC frequency
    Study

    n: not reported in source

    Hippocampal CA1 pyramidal cells and stratum radiatum inhibitory interneurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 microM · bath applicationAs given in this study.

    Source sentences

    Summary
    Bath application of Noopept (1 microM) significantly increased the frequency of spike-dependant spontaneous IPSCs whereas spike-independent mIPSCs remained unchanged.
    1 context sentence
    Summary · context
    Effects of newly synthesized nootropic and anxiolytic dipeptide Noopept on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration.
  2. 02LabEx vivo tissueMechanism

    In hippocampal CA1 pyramidal cells, Noopept did not change spike-independent miniature inhibitory postsynaptic currents.

    In plain wordsIn lab tests, Noopept did not change spike-independent miniature inhibitory signals in hippocampal cells.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeMiniature IPSCs
    Study

    n: not reported in source

    Hippocampal CA1 pyramidal cells and stratum radiatum inhibitory interneurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 microM · bath applicationAs given in this study.

    Source sentences

    Summary
    Bath application of Noopept (1 microM) significantly increased the frequency of spike-dependant spontaneous IPSCs whereas spike-independent mIPSCs remained unchanged.
    1 context sentence
    Summary · context
    Effects of newly synthesized nootropic and anxiolytic dipeptide Noopept on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration.
  3. 03LabEx vivo tissueMechanism

    In stratum radiatum interneurons, current-clamp recordings confirmed inhibitory interneuron activation as a mechanism of Noopept action.

    In plain wordsIn lab tests, recordings confirmed that Noopept activated inhibitory nerve cells in the hippocampus.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseInhibitory interneuron activation
    Study

    n: not reported in source

    Hippocampal CA1 pyramidal cells and stratum radiatum inhibitory interneurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · bath applicationAs given in this study.

    Source sentences

    Summary
    Results of current clamp recording of inhibitory interneurons residing in stratum radiatum confirmed this suggestion.
    2 context sentences
    Summary · context
    It was suggested that Noopept mediates its effect due to the activation of inhibitory interneurons terminating on CA1 pyramidal cells.
    Summary · context
    Effects of newly synthesized nootropic and anxiolytic dipeptide Noopept on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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