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Study · Randomized controlled trial · 2010

4 results

Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans.

Hurlemann R, Patin A, Onur OA, Cohen MX, Baumgartner T, Metzler S, Dziobek I, Gallinat J, Wagner M, Maier W, Kendrick KM

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Apr 2010Cited by 539 (Europe PMC)

PMID20371820 (opens in a new tab)PMCIDPMC6632777 (opens in a new tab)DOI10.1523/jneurosci.5538-09.2010 (opens in a new tab)PepBankPUB-20371820
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin potentiated the learning advantage of social over nonsocial reinforcement.

    In plain wordsIn healthy men, intranasal oxytocin boosted the learning advantage of social feedback over nonsocial feedback.

    Peptide
    Oxytocin
    Outcome
    IncreaseSocially reinforced learning performance
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal OT potentiated this social reinforcement advantage
    2 context sentences
    Summary · context
    Results in control groups showed that learning performance was improved when social rather than nonsocial reinforcement was used.
    Summary · context
    The current double-blind experiments on healthy adult male volunteers
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin greatly increased emotional empathy for both positive and negative valence stimuli.

    In plain wordsIn healthy men, intranasal oxytocin raised emotional empathy for both positive and negative stimuli.

    Peptide
    Oxytocin
    Outcome
    IncreaseEmotional empathy
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    greatly increased emotional, but not cognitive, empathy in response to both positive and negative valence stimuli.
    1 context sentence
    Summary · context
    The current double-blind experiments on healthy adult male volunteers
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin did not increase cognitive empathy.

    In plain wordsIn healthy men, intranasal oxytocin did not raise cognitive empathy.

    Peptide
    Oxytocin
    Outcome
    No significant changeCognitive empathy
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    greatly increased emotional, but not cognitive, empathy in response to both positive and negative valence stimuli.
    1 context sentence
    Summary · context
    The current double-blind experiments on healthy adult male volunteers
  4. 04HumanRandomized controlled trialEfficacy outcome

    After oxytocin treatment, emotional empathy responses in men rose to levels similar to those in untreated women.

    In plain wordsAfter oxytocin, men's emotional empathy rose to a level similar to that of untreated women.

    Peptide
    Oxytocin
    Outcome
    IncreaseEmotional empathy in men relative to untreated women
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Interestingly, after OT treatment, emotional empathy responses in men were raised to levels similar to those found in untreated women.
    1 context sentence
    Summary · context
    The current double-blind experiments on healthy adult male volunteers

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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