Skip to content

Study · Not a test of the peptide alone · 2010

4 results

Expression of peptide NAP in rat retinal Müller cells prevents hypoxia-induced retinal injuries and promotes retinal neurons growth.

Zheng Y, Zeng H, She H, Liu H, Sun N

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie25 Feb 2010Cited by 19 (Europe PMC)

PMID20359852 (opens in a new tab)DOI10.1016/j.biopha.2010.01.016 (opens in a new tab)PepBankPUB-20359852
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Davunetide.

  1. 01LabNot a test of Davunetide aloneIn vitro (cells)Efficacy outcome

    In rat retinal Müller cells under hypoxia, NT4-NAP transfection reduced cytotoxicity.

    In plain wordsIn cells, the NT4-NAP gene construct reduced toxicity in rat retinal Müller cells under hypoxia.

    Peptide
    Davunetide
    Outcome
    DecreaseHypoxic Müller cell cytotoxicity
    Study

    ratn: not reported in source

    Hypoxic retinal Müller cells transfected with NT4-NAP
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Functional analyses of RMC cells transfected with NAP revealed the remarkably reduced cytotoxicity and apoptosis of the cells under hypoxia.
    2 context sentences
    Summary · context
    Here, we have developed a novel NT4-NAP fusion gene by attaching the 5' nonfunctional preproregion of neurotrophin 4 (NT4) to NAP cDNA.
    Summary · context
    Recombinant adeno-associated virus was established to introduce NT4-NAP construct into cultured rat retinal Müller cells (RMC), resulting in sustained high level NAP production from stable transfection.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

  2. 02LabNot a test of Davunetide aloneIn vitro (cells)Efficacy outcome

    In rat retinal Müller cells under hypoxia, NT4-NAP transfection reduced apoptosis.

    In plain wordsIn cells, the NT4-NAP gene construct reduced rat retinal Müller cell death under hypoxia.

    Peptide
    Davunetide
    Outcome
    DecreaseHypoxic Müller cell apoptosis
    Study

    ratn: not reported in source

    Hypoxic retinal Müller cells transfected with NT4-NAP
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Functional analyses of RMC cells transfected with NAP revealed the remarkably reduced cytotoxicity and apoptosis of the cells under hypoxia.
    2 context sentences
    Summary · context
    Here, we have developed a novel NT4-NAP fusion gene by attaching the 5' nonfunctional preproregion of neurotrophin 4 (NT4) to NAP cDNA.
    Summary · context
    Recombinant adeno-associated virus was established to introduce NT4-NAP construct into cultured rat retinal Müller cells (RMC), resulting in sustained high level NAP production from stable transfection.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

  3. 03LabNot a test of Davunetide aloneIn vitro (cells)Efficacy outcome

    In rat retinal neural cells, coculture with transfected RMC-NAP cells protected against hypoxia-induced damage.

    In plain wordsIn cells, coculture with NT4-NAP-transfected cells protected rat retinal neural cells against hypoxic damage.

    Peptide
    Davunetide
    Outcome
    DecreaseRetinal neural cell hypoxic damage
    Study

    ratn: not reported in source

    Primary retinal neural cells cocultured with transfected RMC-NAP cells
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Furthermore, coculturing of transfected RMC-NAP cells with primary rat retinal neural cells offer marked protection to the latter against hypoxia induced cellular damages.
    2 context sentences
    Summary · context
    Here, we have developed a novel NT4-NAP fusion gene by attaching the 5' nonfunctional preproregion of neurotrophin 4 (NT4) to NAP cDNA.
    Summary · context
    Recombinant adeno-associated virus was established to introduce NT4-NAP construct into cultured rat retinal Müller cells (RMC), resulting in sustained high level NAP production from stable transfection.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

  4. 04LabNot a test of Davunetide aloneIn vitro (cells)Activity measurement

    In rat retinal Müller cells, viral NT4-NAP transfection produced sustained high NAP levels.

    In plain wordsIn cells, viral NT4-NAP transfection produced sustained high NAP levels in rat retinal Müller cells.

    Peptide
    Davunetide
    Outcome
    IncreaseSustained NAP production
    Study

    ratn: not reported in source

    Retinal Müller cells transfected with NT4-NAP
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Recombinant adeno-associated virus was established to introduce NT4-NAP construct into cultured rat retinal Müller cells (RMC), resulting in sustained high level NAP production from stable transfection.
    1 context sentence
    Summary · context
    Here, we have developed a novel NT4-NAP fusion gene by attaching the 5' nonfunctional preproregion of neurotrophin 4 (NT4) to NAP cDNA.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.