Skip to content

Study · Animal study (in vivo) · rat · 2010

2 results

High-fat intake induced by mu-opioid activation of the nucleus accumbens is inhibited by Y1R-blockade and MC3/4R- stimulation.

Zheng H, Townsend RL, Shin AC, Patterson LM, Phifer CB, Berthoud HR

Brain research24 Mar 2010Cited by 31 (Europe PMC)

PMID20346352 (opens in a new tab)PMCIDPMC2926229 (opens in a new tab)DOI10.1016/j.brainres.2010.03.061 (opens in a new tab)PepBankPUB-20346352
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, prior lateral-ventricle MTII dose-dependently decreased high-fat intake induced by nucleus accumbens injection of the mu-opioid agonist DAMGO.

    In plain wordsIn rats, melanotan II given into the brain reduced high-fat food intake triggered by a mu-opioid drug, with larger doses reducing it more.

    Peptide
    Melanotan II
    Outcome
    DecreaseDAMGO-induced high-fat intake
    Study

    ratn: not reported in source

    Satiated rats with nucleus accumbens DAMGO injection
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · lateral ventricle (intracerebroventricular)As given in this study (rat).

    Source sentences

    Summary
    Prior administration of the selective Y1R antagonist 1229U91 or the MC3/4R agonist MTII into the lateral ventricle (LV) dose-dependently decreased high-fat intake induced by nucleus accumbens injection of the mu-opioid receptor agonist DAMGO.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats switched from chow to a high-fat diet, MTII also decreased high-fat feeding, but less efficiently than against DAMGO-induced intake.

    In plain wordsIn rats switched to a high-fat diet, melanotan II also reduced high-fat eating, but less than it reduced eating triggered by DAMGO.

    Peptide
    Melanotan II
    Outcome
    DecreaseHigh-fat intake after switch from chow to high-fat diet
    Study

    ratn: not reported in source

    Satiated rats with nucleus accumbens DAMGO injection
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · lateral ventricle (intracerebroventricular)As given in this study (rat).

    Source sentences

    Summary
    Both drugs also decreased high-fat feeding induced by switching rats from regular chow to high-fat diet, but less efficiently than when DAMGO-induced.
    1 context sentence
    Summary · context
    Prior administration of the selective Y1R antagonist 1229U91 or the MC3/4R agonist MTII into the lateral ventricle (LV) dose-dependently decreased high-fat intake induced by nucleus accumbens injection of the mu-opioid receptor agonist DAMGO.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.