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Study · Case report or series · n = 1 · 2011

3 results

Successful treatment of advanced bisphosphonate-related osteonecrosis of the mandible with adjunctive teriparatide therapy.

Lee JJ, Cheng SJ, Jeng JH, Chiang CP, Lau HP, Kok SH

Head & neck22 Mar 2010Cited by 49 (Europe PMC)

PMID20310042 (opens in a new tab)DOI10.1002/hed.21380 (opens in a new tab)PepBankPUB-20310042
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In a woman with alendronate-related mandibular osteonecrosis, oral mucosa completely regrew after teriparatide initiation.

    In plain wordsIn a woman with jawbone damage related to alendronate, mouth tissue completely regrew after teriparatide treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOral mucosa regrowth
    Study

    n = 1

    Comparator
    Before teriparatide treatment
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    The oral mucosa completely regrew, and pain subsided 4 weeks after the initiation of teriparatide administration.
    3 context sentences
    Summary · context
    A 78-year-old osteoporotic woman with osteonecrosis of the mandible related to alendronate therapy was referred for treatment.
    Summary · context
    The disease was unresponsive to conservative therapy, including antibacterial mouth rinse, antibiotics, and minor surgical debridement.
    Summary · context
    Teriparatide, a human recombinant pararthyroid hormone peptide 1-34, was then used for treatment.
  2. 02HumanCase report or seriesEfficacy outcome

    In a woman with alendronate-related mandibular osteonecrosis, pain subsided after teriparatide initiation.

    In plain wordsIn a woman with jawbone damage related to alendronate, pain subsided after teriparatide treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasePain
    Study

    n = 1

    Comparator
    Before teriparatide treatment
    Outcome group
    Pain · Musculoskeletal
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    The oral mucosa completely regrew, and pain subsided 4 weeks after the initiation of teriparatide administration.
    3 context sentences
    Summary · context
    A 78-year-old osteoporotic woman with osteonecrosis of the mandible related to alendronate therapy was referred for treatment.
    Summary · context
    The disease was unresponsive to conservative therapy, including antibacterial mouth rinse, antibiotics, and minor surgical debridement.
    Summary · context
    Teriparatide, a human recombinant pararthyroid hormone peptide 1-34, was then used for treatment.
  3. 03HumanCase report or seriesEfficacy outcome

    In a woman with alendronate-related mandibular osteonecrosis, progressive bone regeneration occurred during and after teriparatide therapy.

    In plain wordsIn a woman with jawbone damage related to alendronate, bone progressively regrew during and after teriparatide treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone regeneration
    Study

    n = 1

    Comparator
    Before teriparatide treatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Progressive bone regeneration was found during and after the 6-month period of teriparatide therapy.
    3 context sentences
    Summary · context
    A 78-year-old osteoporotic woman with osteonecrosis of the mandible related to alendronate therapy was referred for treatment.
    Summary · context
    The disease was unresponsive to conservative therapy, including antibacterial mouth rinse, antibiotics, and minor surgical debridement.
    Summary · context
    Teriparatide, a human recombinant pararthyroid hormone peptide 1-34, was then used for treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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