Secretagogue type, sex-steroid milieu, and abdominal visceral adiposity individually determine secretagogue-stimulated cortisol secretion.

Iranmanesh A, Bowers CY, Veldhuis JD

European journal of endocrinology18 Mar 2010Cited by 1 (Europe PMC)

PMID20299490PMCIDPMC3108036DOI10.1530/eje-10-0149PepBankPUB-20299490

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. 2 results from people.

01HumanRandomized controlled trialEfficacy outcome
In 42 healthy men, GHRP‑2 raised stimulated peak cortisol (616 nmol/l) above saline, somatostatin and GHRH (grand mean 420 nmol/l).
In plain wordsIn 42 healthy men, GHRP‑2 raised peak cortisol more than saline, somatostatin or GHRH did.
Peptide
GHRP-2
Outcome
IncreaseStimulated peak cortisol, GHRP-2 vs saline, somatostatin and GHRH
Study
n = 42
Comparator
Saline, somatostatin or GHRH
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
Stimulated peak cortisol
616 nmol/l
GHRP-2
Stimulated peak cortisol
420 nmol/l
saline, somatostatin or GHRH (grand mean)
Source sentences
Summary
In contrast, stimulated peak cortisol concentrations were strongly determined by secretagogue type (PGHRP-2 (616+/-42)>saline=SS=GHRH (grand mean 420+/-21).
2 context sentences(design, population, supporting numbers)
Summary · context
To address this issue, cortisol was measured in archival sera obtained at 10-min intervals for 5 h in 42 healthy men administered double placebo, placebo and testosterone, testosterone and dutasteride (to block 5alpha-reductases type I and type II), or testosterone and anastrozole (to block aromatas…
Summary · context
Subjects received i.v. injection of saline, GHRH, GH-releasing peptide-2 (GHRP-2), somatostatin (SS), and GHRP-2/GHRH/l-arginine (triple stimulus) each on separate mornings fasting.
Report a problemFND-2029949001
02HumanRandomized controlled trialOther
In healthy men, pulsatile cortisol secretion after GHRP‑2 injection increased with age (R(2)=0.16, P=0.012).
In plain wordsIn healthy men, the cortisol pulses after GHRP‑2 were larger in older men.
Peptide
GHRP-2
Outcome
IncreasePulsatile cortisol secretion after GHRP-2 and age
Study
n = 42
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
R(2)
0.16
pulsatile cortisol secretion vs age after GHRP-2
Source sentences
Summary
After GHRP-2 injection, pulsatile cortisol secretion increased with age (R(2)=0.16, P=0.012).
2 context sentences(design, population, supporting numbers)
Summary · context
To address this issue, cortisol was measured in archival sera obtained at 10-min intervals for 5 h in 42 healthy men administered double placebo, placebo and testosterone, testosterone and dutasteride (to block 5alpha-reductases type I and type II), or testosterone and anastrozole (to block aromatas…
Summary · context
Subjects received i.v. injection of saline, GHRH, GH-releasing peptide-2 (GHRP-2), somatostatin (SS), and GHRP-2/GHRH/l-arginine (triple stimulus) each on separate mornings fasting.
Report a problemFND-2029949003

Studies that did not test the peptide alone3

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

03HumanNot a test of GHRP-2 aloneRandomized controlled trialEfficacy outcome
In 42 healthy men, the triple stimulus (GHRP‑2, GHRH and L-arginine) raised stimulated peak cortisol (868 nmol/l) above GHRP‑2 alone and the other secretagogues.
In plain wordsIn 42 healthy men, the three-part stimulus raised peak cortisol more than GHRP‑2 alone or the other agents did.
Peptide
GHRP-2
Outcome
IncreaseStimulated peak cortisol, triple stimulus
Study
n = 42
Comparator
GHRP-2, saline, somatostatin and GHRH
Outcome group
Stress hormones · Endocrine and hormones
Measurements
Stimulated peak cortisol
868 nmol/l
triple stimulus
Source sentences
Summary
In contrast, stimulated peak cortisol concentrations were strongly determined by secretagogue type (PGHRP-2 (616+/-42)>saline=SS=GHRH (grand mean 420+/-21).
2 context sentences(design, population, supporting numbers)
Summary · context
To address this issue, cortisol was measured in archival sera obtained at 10-min intervals for 5 h in 42 healthy men administered double placebo, placebo and testosterone, testosterone and dutasteride (to block 5alpha-reductases type I and type II), or testosterone and anastrozole (to block aromatas…
Summary · context
Subjects received i.v. injection of saline, GHRH, GH-releasing peptide-2 (GHRP-2), somatostatin (SS), and GHRP-2/GHRH/l-arginine (triple stimulus) each on separate mornings fasting.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2029949002
04HumanNot a test of GHRP-2 aloneRandomized controlled trialOther
In healthy men, pulsatile cortisol secretion after the triple stimulus correlated inversely with serum DHT concentrations (R(2)=0.53, P=0.026).
In plain wordsIn healthy men, cortisol pulses after the three-part stimulus were smaller when blood DHT was higher.
Peptide
GHRP-2
Outcome
DecreasePulsatile cortisol secretion after triple stimulus and DHT
Study
n = 42
Outcome group
Stress hormones · Endocrine and hormones
Measurements
R(2)
0.53
pulsatile cortisol vs DHT after triple stimulus
Source sentences
Summary
After the triple stimulus, pulsatile cortisol secretion correlated i) inversely with serum 5alpha-dihydrotestosterone (DHT) concentrations (R(2)=0.53, P=0.026) and ii) directly with computerized tomography-estimated AVF (R(2)=0.11, P=0.038).
2 context sentences(design, population, supporting numbers)
Summary · context
To address this issue, cortisol was measured in archival sera obtained at 10-min intervals for 5 h in 42 healthy men administered double placebo, placebo and testosterone, testosterone and dutasteride (to block 5alpha-reductases type I and type II), or testosterone and anastrozole (to block aromatas…
Summary · context
Subjects received i.v. injection of saline, GHRH, GH-releasing peptide-2 (GHRP-2), somatostatin (SS), and GHRP-2/GHRH/l-arginine (triple stimulus) each on separate mornings fasting.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2029949004
05HumanNot a test of GHRP-2 aloneRandomized controlled trialOther
In healthy men, pulsatile cortisol secretion after the triple stimulus correlated directly with CT-estimated abdominal visceral fat (R(2)=0.11, P=0.038).
In plain wordsIn healthy men, cortisol pulses after the three-part stimulus were larger with more belly fat.
Peptide
GHRP-2
Outcome
IncreasePulsatile cortisol secretion after triple stimulus and abdominal visceral fat
Study
n = 42
Outcome group
Stress hormones · Endocrine and hormones
Measurements
R(2)
0.11
pulsatile cortisol vs AVF after triple stimulus
Source sentences
Summary
After the triple stimulus, pulsatile cortisol secretion correlated i) inversely with serum 5alpha-dihydrotestosterone (DHT) concentrations (R(2)=0.53, P=0.026) and ii) directly with computerized tomography-estimated AVF (R(2)=0.11, P=0.038).
2 context sentences(design, population, supporting numbers)
Summary · context
To address this issue, cortisol was measured in archival sera obtained at 10-min intervals for 5 h in 42 healthy men administered double placebo, placebo and testosterone, testosterone and dutasteride (to block 5alpha-reductases type I and type II), or testosterone and anastrozole (to block aromatas…
Summary · context
Subjects received i.v. injection of saline, GHRH, GH-releasing peptide-2 (GHRP-2), somatostatin (SS), and GHRP-2/GHRH/l-arginine (triple stimulus) each on separate mornings fasting.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-2029949005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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