Involvement of oxytocin in the nucleus tractus solitarii on central cardiovascular control: interactions with glutamate.

Vela C, Diaz-Cabiale Z, Parrado C, Narvaez M, Covenas R, Narvaez JA

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Feb 2010Cited by 11 (Europe PMC)

PMID20228416PepBankPUB-20228416

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In anesthetized rats, a subthreshold dose of OT significantly counteracted the vasodepressor response induced by L-glutamate.
In plain wordsIn anesthetized rats, a very low dose of oxytocin worked against the blood pressure fall caused by glutamate.
Peptide
Oxytocin
Outcome
DecreaseSubthreshold OT effect on GLU-induced vasodepressor response (MAP)
Study
ratn: not reported in source
Anesthetized rats, microinjection into the nucleus tractus solitarii
Comparator
L-glutamate alone
Outcome group
Blood pressure · Cardiovascular
Studied dose
subthreshold dose · microinjection into the nucleus tractus solitariiAs given in this study (rat).
Source sentences
Summary
With regard to the OT/GLU coinjections, a subthreshold dose of OT significantly (p<0.001) counteracted the vasodepressor and bradycardiac responses induced by GLU.
2 context sentences(design, population, supporting numbers)
Summary · context
To clarify the role of endogenous OT in cardiovascular control, one group of anesthetized rats received unilateral microinjections of the OT receptor antagonist [d(CH(2))(5),Tyr(Me)(2),Orn(8)]-vasotocin (OTA) in the nucleus tractus solitarii (NTS) and a second group was injected with specific OT antiserum (Anti-OT).
Summary · context
Mean arterial pressure (MAP) and heart rate (HR) were measured from a femoral catheter.
Report a problemFND-2022841604
02AnimalAnimal study (in vivo)Mechanism
In anesthetized rats, a subthreshold dose of OT significantly counteracted the bradycardiac response induced by L-glutamate.
In plain wordsIn anesthetized rats, a very low dose of oxytocin worked against the heart rate fall caused by glutamate.
Peptide
Oxytocin
Outcome
DecreaseSubthreshold OT effect on GLU-induced bradycardiac response (HR)
Study
ratn: not reported in source
Anesthetized rats, microinjection into the nucleus tractus solitarii
Comparator
L-glutamate alone
Outcome group
Heart function · Cardiovascular
Studied dose
subthreshold dose · microinjection into the nucleus tractus solitariiAs given in this study (rat).
Source sentences
Summary
With regard to the OT/GLU coinjections, a subthreshold dose of OT significantly (p<0.001) counteracted the vasodepressor and bradycardiac responses induced by GLU.
2 context sentences(design, population, supporting numbers)
Summary · context
To clarify the role of endogenous OT in cardiovascular control, one group of anesthetized rats received unilateral microinjections of the OT receptor antagonist [d(CH(2))(5),Tyr(Me)(2),Orn(8)]-vasotocin (OTA) in the nucleus tractus solitarii (NTS) and a second group was injected with specific OT antiserum (Anti-OT).
Summary · context
Mean arterial pressure (MAP) and heart rate (HR) were measured from a femoral catheter.
Report a problemFND-2022841605

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anesthetized rats, the OT receptor antagonist OTA significantly decreased the vasopressor response elicited by an effective dose of OT.
In plain wordsIn anesthetized rats, a drug blocking the oxytocin receptor reduced the blood pressure rise caused by oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOT receptor antagonist effect on OT-induced pressor response (MAP)
Study
ratn: not reported in source
Anesthetized rats, microinjection into the nucleus tractus solitarii
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
OTA significantly (p<0.01) decreased the vasopressor
3 context sentences(design, population, supporting numbers)
Summary · context
OTA significantly (p<0.01) decreased the vasopressor and tachycardiac long-lasting response elicited by an effective dose of OT.
Summary · context
To clarify the role of endogenous OT in cardiovascular control, one group of anesthetized rats received unilateral microinjections of the OT receptor antagonist [d(CH(2))(5),Tyr(Me)(2),Orn(8)]-vasotocin (OTA) in the nucleus tractus solitarii (NTS) and a second group was injected with specific OT antiserum (Anti-OT).
Summary · context
Mean arterial pressure (MAP) and heart rate (HR) were measured from a femoral catheter.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2022841601
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anesthetized rats, the OT receptor antagonist OTA significantly decreased the tachycardiac response elicited by an effective dose of OT.
In plain wordsIn anesthetized rats, a drug blocking the oxytocin receptor reduced the heart rate rise caused by oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOT receptor antagonist effect on OT-induced tachycardia (HR)
Study
ratn: not reported in source
Anesthetized rats, microinjection into the nucleus tractus solitarii
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
OTA significantly (p<0.01) decreased the vasopressor and tachycardiac long-lasting response elicited by an effective dose of OT.
2 context sentences(design, population, supporting numbers)
Summary · context
To clarify the role of endogenous OT in cardiovascular control, one group of anesthetized rats received unilateral microinjections of the OT receptor antagonist [d(CH(2))(5),Tyr(Me)(2),Orn(8)]-vasotocin (OTA) in the nucleus tractus solitarii (NTS) and a second group was injected with specific OT antiserum (Anti-OT).
Summary · context
Mean arterial pressure (MAP) and heart rate (HR) were measured from a femoral catheter.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2022841602
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anesthetized rats, microinjection of anti-OT antibody did not change MAP or HR compared with the control group.
In plain wordsIn anesthetized rats, blocking the body's own oxytocin with an antibody did not change blood pressure or heart rate compared with controls.
Peptide
Oxytocin
Outcome
No significant changeAnti-OT antiserum effect on MAP and HR
Study
ratn: not reported in source
Anesthetized rats, microinjection into the nucleus tractus solitarii
Comparator
Control group
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Microinjections of Anti-OT antibody did not modify the values of MAP and HR compared with the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
To clarify the role of endogenous OT in cardiovascular control, one group of anesthetized rats received unilateral microinjections of the OT receptor antagonist [d(CH(2))(5),Tyr(Me)(2),Orn(8)]-vasotocin (OTA) in the nucleus tractus solitarii (NTS) and a second group was injected with specific OT antiserum (Anti-OT).
Summary · context
Mean arterial pressure (MAP) and heart rate (HR) were measured from a femoral catheter.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2022841603
06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anesthetized rats, coinjection of subthreshold doses of OT and glutamate produced no change in MAP or HR.
In plain wordsIn anesthetized rats, injecting very low doses of oxytocin and glutamate together did not change blood pressure or heart rate.
Peptide
Oxytocin
Outcome
No significant changeCoinjection of subthreshold OT and GLU on MAP and HR
Study
ratn: not reported in source
Anesthetized rats, microinjection into the nucleus tractus solitarii
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
The coinjection of subthreshold doses of OT and GLU did not produce a change in MAP or in HR.
2 context sentences(design, population, supporting numbers)
Summary · context
To clarify the role of endogenous OT in cardiovascular control, one group of anesthetized rats received unilateral microinjections of the OT receptor antagonist [d(CH(2))(5),Tyr(Me)(2),Orn(8)]-vasotocin (OTA) in the nucleus tractus solitarii (NTS) and a second group was injected with specific OT antiserum (Anti-OT).
Summary · context
Mean arterial pressure (MAP) and heart rate (HR) were measured from a femoral catheter.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2022841606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

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