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Study · Measured the body's own peptide · 2010

1 result

Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression.

Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR, Kublaoui BM

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Mar 2010Cited by 106 (Europe PMC)

PMID20220015 (opens in a new tab)PMCIDPMC3285557 (opens in a new tab)DOI10.1523/jneurosci.5444-09.2010 (opens in a new tab)PepBankPUB-20220015
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In Sim1-deficient mice, hypothalamic oxytocin (Oxt) mRNA was markedly decreased.

    In plain wordsIn mice lacking Sim1, the body's own oxytocin messenger RNA in the hypothalamus was much lower.

    Peptide
    Oxytocin
    Outcome
    DecreaseHypothalamic oxytocin mRNA
    Study

    mousen: not reported in source

    Conditional Sim1 homozygotes and germ line Sim1 heterozygotes
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Finally, we showed that conditional Sim1 homozygotes and germ line Sim1 heterozygotes exhibit a remarkable decrease in hypothalamic oxytocin (Oxt) and PVN melanocortin 4 receptor (Mc4r) mRNA.
    1 context sentence
    Summary · context
    We conditionally deleted Sim1 after birth using CaMKII-Cre (alpha-calcium/calmodulin-dependent protein kinase II-Cre) lines to recombine a floxed Sim1 allele.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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