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Study · Animal study (in vivo) · rat · 2010

22 results

The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status.

Granado M, García-Cáceres C, Frago LM, Argente J, Chowen JA

Endocrinology10 Mar 2010Cited by 10 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study22

16 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, GHRP‑6 did not improve hyperglycemia compared with saline treatment.

    In plain wordsIn rats with diabetes, GHRP‑6 did not improve high blood sugar compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeHyperglycemia
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Insulin, but not GHRP-6, improved these parameters (P < 0.001 for all), as well as the diabetes-induced increase in hypothalamic mRNA levels of neuropeptide Y and agouti-related peptide and decrease in proopiomelanocortin.
    2 context sentences
    Summary · context
    Rats receiving saline suffered hyperglycemia, hyperphagia, polydipsia, and weight loss.
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, GHRP‑6 did not improve hyperphagia compared with saline treatment.

    In plain wordsIn rats with diabetes, GHRP‑6 did not reduce excessive eating compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeHyperphagia
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Insulin, but not GHRP-6, improved these parameters (P < 0.001 for all), as well as the diabetes-induced increase in hypothalamic mRNA levels of neuropeptide Y and agouti-related peptide and decrease in proopiomelanocortin.
    2 context sentences
    Summary · context
    Rats receiving saline suffered hyperglycemia, hyperphagia, polydipsia, and weight loss.
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, GHRP‑6 did not improve polydipsia compared with saline treatment.

    In plain wordsIn rats with diabetes, GHRP‑6 did not reduce excessive drinking compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changePolydipsia
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Insulin, but not GHRP-6, improved these parameters (P < 0.001 for all), as well as the diabetes-induced increase in hypothalamic mRNA levels of neuropeptide Y and agouti-related peptide and decrease in proopiomelanocortin.
    2 context sentences
    Summary · context
    Rats receiving saline suffered hyperglycemia, hyperphagia, polydipsia, and weight loss.
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, GHRP‑6 did not improve weight loss compared with saline treatment.

    In plain wordsIn rats with diabetes, GHRP‑6 did not improve weight loss compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeWeight loss
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Insulin, but not GHRP-6, improved these parameters (P < 0.001 for all), as well as the diabetes-induced increase in hypothalamic mRNA levels of neuropeptide Y and agouti-related peptide and decrease in proopiomelanocortin.
    2 context sentences
    Summary · context
    Rats receiving saline suffered hyperglycemia, hyperphagia, polydipsia, and weight loss.
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, GHRP‑6 did not reverse the diabetes-induced increase in hypothalamic neuropeptide Y mRNA.

    In plain wordsIn rats with diabetes, GHRP‑6 did not reverse the rise in hypothalamic neuropeptide Y gene expression compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeHypothalamic neuropeptide Y mRNA
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Insulin, but not GHRP-6, improved these parameters (P < 0.001 for all), as well as the diabetes-induced increase in hypothalamic mRNA levels of neuropeptide Y and agouti-related peptide and decrease in proopiomelanocortin.
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, GHRP‑6 did not reverse the diabetes-induced increase in hypothalamic agouti-related peptide mRNA.

    In plain wordsIn rats with diabetes, GHRP‑6 did not reverse the rise in hypothalamic agouti-related peptide gene expression compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeHypothalamic agouti-related peptide mRNA
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Insulin, but not GHRP-6, improved these parameters (P < 0.001 for all), as well as the diabetes-induced increase in hypothalamic mRNA levels of neuropeptide Y and agouti-related peptide and decrease in proopiomelanocortin.
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, GHRP‑6 did not reverse the diabetes-induced decrease in hypothalamic proopiomelanocortin mRNA.

    In plain wordsIn rats with diabetes, GHRP‑6 did not reverse reduced hypothalamic proopiomelanocortin gene expression compared with saline.

    Peptide
    GHRP-6
    Outcome
    No significant changeHypothalamic proopiomelanocortin mRNA
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Insulin, but not GHRP-6, improved these parameters (P < 0.001 for all), as well as the diabetes-induced increase in hypothalamic mRNA levels of neuropeptide Y and agouti-related peptide and decrease in proopiomelanocortin.
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, GHRP‑6 further decreased cocaine amphetamine-related transcript mRNA levels compared with saline treatment.

    In plain wordsIn rats with diabetes, GHRP‑6 further reduced cocaine amphetamine-related transcript gene expression compared with saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseCocaine amphetamine-related transcript mRNA
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Cocaine amphetamine-related transcript mRNA levels were also reduced in diabetic rats, with GHRP-6 inducing a further decrease (P < 0.03) and insulin an increase.
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, insulin plus GHRP‑6 increased weight gain compared with insulin alone.

    In plain wordsIn rats with diabetes, insulin plus GHRP‑6 increased weight gain compared with insulin alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseWeight gain
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    insulin alone
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, insulin plus GHRP‑6 increased serum leptin compared with insulin alone.

    In plain wordsIn rats with diabetes, insulin plus GHRP‑6 increased blood leptin compared with insulin alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseSerum leptin
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    insulin alone
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, GHRP‑6 increased epididymal adipose fatty acid synthase gene expression.

    In plain wordsIn rats with diabetes, GHRP‑6 increased fat-tissue fatty acid synthase gene expression compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseAdipose fatty acid synthase gene expression
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 treatment increased FAS and glucose transporter-4 gene expression and potentiated insulin's effect on epididymal fat mass, adipocyte size (P < 0.001), FAS (P < 0.001), and glucose transporter-4 (P < 0.05).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, GHRP‑6 increased epididymal adipose glucose transporter-4 gene expression.

    In plain wordsIn rats with diabetes, GHRP‑6 increased fat-tissue glucose transporter-4 gene expression compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseAdipose glucose transporter-4 gene expression
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline-treated diabetic rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 treatment increased FAS and glucose transporter-4 gene expression and potentiated insulin's effect on epididymal fat mass, adipocyte size (P < 0.001), FAS (P < 0.001), and glucose transporter-4 (P < 0.05).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, adding GHRP‑6 potentiated insulin's effect on epididymal fat mass.

    In plain wordsIn rats with diabetes, adding GHRP‑6 increased insulin's effect on epididymal fat mass compared with insulin alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseInsulin-associated epididymal fat mass
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    insulin alone
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 treatment increased FAS and glucose transporter-4 gene expression and potentiated insulin's effect on epididymal fat mass, adipocyte size (P < 0.001), FAS (P < 0.001), and glucose transporter-4 (P < 0.05).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, adding GHRP‑6 potentiated insulin's effect on adipocyte size.

    In plain wordsIn rats with diabetes, adding GHRP‑6 increased insulin's effect on fat-cell size compared with insulin alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseInsulin-associated adipocyte size
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    insulin alone
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 treatment increased FAS and glucose transporter-4 gene expression and potentiated insulin's effect on epididymal fat mass, adipocyte size (P < 0.001), FAS (P < 0.001), and glucose transporter-4 (P < 0.05).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, adding GHRP‑6 potentiated insulin's effect on fatty acid synthase expression.

    In plain wordsIn rats with diabetes, adding GHRP‑6 increased insulin's effect on fatty acid synthase expression compared with insulin alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseInsulin-associated fatty acid synthase expression
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    insulin alone
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 treatment increased FAS and glucose transporter-4 gene expression and potentiated insulin's effect on epididymal fat mass, adipocyte size (P < 0.001), FAS (P < 0.001), and glucose transporter-4 (P < 0.05).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.
  16. 16AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, adding GHRP‑6 potentiated insulin's effect on glucose transporter-4 expression.

    In plain wordsIn rats with diabetes, adding GHRP‑6 increased insulin's effect on glucose transporter-4 expression compared with insulin alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseInsulin-associated glucose transporter-4 expression
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    insulin alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 8 wkAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 treatment increased FAS and glucose transporter-4 gene expression and potentiated insulin's effect on epididymal fat mass, adipocyte size (P < 0.001), FAS (P < 0.001), and glucose transporter-4 (P < 0.05).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.

Studies that did not test the peptide alone6

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 17AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, insulin plus GHRP‑6 increased epididymal fat mass compared with saline.

    In plain wordsIn rats with diabetes, insulin plus GHRP‑6 increased epididymal fat mass compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseEpididymal fat mass
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline
    Outcome group
    Body composition · Metabolic and weight

    Source sentences

    Summary
    Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 18AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, insulin plus GHRP‑6 increased weight gain compared with saline.

    In plain wordsIn rats with diabetes, insulin plus GHRP‑6 increased weight gain compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseWeight gain
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 19AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, insulin plus GHRP‑6 increased weight gain compared with GHRP‑6 alone.

    In plain wordsIn rats with diabetes, insulin plus GHRP‑6 increased weight gain compared with GHRP‑6 alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseWeight gain
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    GHRP-6 alone
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 20AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, insulin plus GHRP‑6 increased epididymal fat mass compared with GHRP‑6 alone.

    In plain wordsIn rats with diabetes, insulin plus GHRP‑6 increased epididymal fat mass compared with GHRP‑6 alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseEpididymal fat mass
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    GHRP-6 alone
    Outcome group
    Body composition · Metabolic and weight

    Source sentences

    Summary
    Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  5. 21AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, insulin plus GHRP‑6 increased serum leptin compared with saline.

    In plain wordsIn rats with diabetes, insulin plus GHRP‑6 increased serum leptin compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreaseSerum leptin
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    saline
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  6. 22AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, insulin plus GHRP‑6 increased serum leptin compared with GHRP‑6 alone.

    In plain wordsIn rats with diabetes, insulin plus GHRP‑6 increased serum leptin compared with GHRP‑6 alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseSerum leptin
    Study

    ratn: not reported in source

    streptozotocin-induced diabetes
    Comparator
    GHRP-6 alone
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Diabetic rats receiving insulin plus GHRP-6 gained more weight and had increased epididymal fat mass and serum leptin levels compared with all other groups (P < 0.001).
    1 context sentence
    Summary · context
    Streptozotocin-induced diabetic rats received saline, GHRP-6, insulin, or insulin plus GHRP-6 once daily for 8 wk.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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