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Study · In vitro (cells) · 2010

3 results

Do GnRH analogues directly affect human endometrial epithelial cell gene expression?

Zhang X, Bocca S, Franchi A, Anderson S, Kaur M, Bajic VB, Oehninger S

Molecular human reproduction4 Mar 2010Cited by 4 (Europe PMC)

PMID20203127 (opens in a new tab)DOI10.1093/molehr/gaq012 (opens in a new tab)PepBankPUB-20203127
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In Ishikawa cells, ganirelix alone had no effect on gene expression at 6 and 24 hours.

    In plain wordsIn cells, ganirelix alone did not change gene expression at 6 and 24 hours.

    Peptide
    Ganirelix
    Outcome
    No significant changeGene expression after ganirelix alone
    Study

    humann: not reported in source

    Ishikawa endometrial epithelial cells
    Comparator
    No GnRH analogue
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 and 24 hAs given in this study (human).

    Source sentences

    Summary
    At 6 and 24 h, neither LA nor GA alone had an effect on gene expression.
    1 context sentence
    Summary · context
    We examined whether Gonadotrophin-releasing hormone (GnRH) analogues [leuprolide acetate (LA) and ganirelix acetate (GA)] modulate gene expression in Ishikawa cells used as surrogate for human endometrial epithelial cells in vitro.
  2. 02LabIn vitro (cells)Mechanism

    In Ishikawa cells, E(2) plus P4 followed by ganirelix had no effect on gene expression, like steroid treatment alone.

    In plain wordsIn cells, steroid treatment followed by ganirelix did not change gene expression, like steroid treatment alone.

    Peptide
    Ganirelix
    Outcome
    No significant changeGene expression after steroid treatment followed by ganirelix
    Study

    humann: not reported in source

    Ishikawa endometrial epithelial cells
    Comparator
    E(2) plus P4 without ganirelix
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    E(2) + P4 treatment for 4 days, alone or followed by GA, had no effect
    1 context sentence
    Summary · context
    We examined whether Gonadotrophin-releasing hormone (GnRH) analogues [leuprolide acetate (LA) and ganirelix acetate (GA)] modulate gene expression in Ishikawa cells used as surrogate for human endometrial epithelial cells in vitro.
  3. 03LabIn vitro (cells)Mechanism

    In Ishikawa cells, ganirelix did not modify intracellular cAMP levels.

    In plain wordsIn cells, ganirelix did not change intracellular cAMP levels.

    Peptide
    Ganirelix
    Outcome
    No significant changeIntracellular cAMP
    Study

    humann: not reported in source

    Ishikawa endometrial epithelial cells
    Comparator
    No GnRH analogue
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The GnRH analogues did not modify intracellular cAMP levels.
    1 context sentence
    Summary · context
    We examined whether Gonadotrophin-releasing hormone (GnRH) analogues [leuprolide acetate (LA) and ganirelix acetate (GA)] modulate gene expression in Ishikawa cells used as surrogate for human endometrial epithelial cells in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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