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Study · Not a test of the peptide alone · 2010

2 results

In situ growth of side-chain PEG polymers from functionalized human growth hormone-a new technique for preparation of enhanced protein-polymer conjugates.

Magnusson JP, Bersani S, Salmaso S, Alexander C, Caliceti P

Bioconjugate chemistry1 Apr 2010Cited by 52 (Europe PMC)

PMID20201488 (opens in a new tab)DOI10.1021/bc900468v (opens in a new tab)PepBankPUB-20201488
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking HGH (somatotropin).

  1. 01AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Activity measurement

    In rats, native rh-GH and rh-GH PEGMA showed similar activity at a daily dose of 40 microg.

    In plain wordsIn rats, native growth hormone and rh-GH PEGMA showed similar activity at a daily dose of 40 microg.

    Peptide
    HGH (somatotropin)
    Outcome
    Direction not reportedIn vivo activity at daily dose
    Study

    ratn: not reported in source

    Comparator
    rh-GH PEGMA
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The rh-GH PEGMA exhibited similar activity as the native rh-GH in vivo when a daily dose of 40 microg was administered.
    1 context sentence
    Summary · context
    The rh-GH PEGMA was administered subcutaneously to rats and the activity compared to native rh-GH.

    In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).

  2. 02AnimalNot a test of HGH (somatotropin) aloneAnimal study (in vivo)Pharmacokinetics

    In rats, native rh-GH had lower bioavailability than rh-GH PEGMA at 120 microg with 3 days between injections.

    In plain wordsIn rats, native growth hormone had lower bioavailability than rh-GH PEGMA at 120 microg with 3 days between injections.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseBioavailability with injections three days apart
    Study

    ratn: not reported in source

    Comparator
    rh-GH PEGMA
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    However, when a higher dose of 120 microg was administered with 3 days between injections the bioavailability of the rh-GH PEGMA was significantly better than that of the native.
    1 context sentence
    Summary · context
    The rh-GH PEGMA was administered subcutaneously to rats and the activity compared to native rh-GH.

    In this study, HGH (somatotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking HGH (somatotropin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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