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Study · Not a test of the peptide alone · 2010

4 results

Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes.

Souza RP, de Luca V, Meltzer HY, Lieberman JA, Kennedy JL

The international journal of neuropsychopharmacology3 Mar 2010Cited by 55 (Europe PMC)

PMID20196918 (opens in a new tab)DOI10.1017/s1461145710000167 (opens in a new tab)PepBankPUB-20196918
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneObservational studyOther

    In people with schizophrenia treated with clozapine, the rs2740204 variant in the OXT gene was significantly associated with treatment response.

    In plain wordsIn people with schizophrenia, a variant in the oxytocin gene was linked to how well clozapine worked.

    Peptide
    Oxytocin
    Outcome
    Not applicableOXT gene variant rs2740204 and clozapine treatment response
    Study

    n: not reported in source

    Outcome group
    Psychiatric symptoms · Mental health and mood

    Source sentences

    Summary
    The rs2740204 variant in the OXT gene was significantly associated with treatment response (after 1000 permutations p=0.042)
    1 context sentence
    Summary · context
    Therefore, we evaluated if OXT and OXT receptor (OXTR) genes might play a role in the symptom severity and clozapine treatment response in schizophrenia subjects.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneObservational studyOther

    In people with schizophrenia, the rs2740204 variant in the OXT gene was nominally associated with negative symptoms.

    In plain wordsIn people with schizophrenia, a variant in the oxytocin gene was possibly linked to negative symptoms.

    Peptide
    Oxytocin
    Outcome
    Not applicableOXT gene variant rs2740204 and negative symptoms
    Study

    n: not reported in source

    Outcome group
    Psychiatric symptoms · Mental health and mood

    Source sentences

    Summary
    The rs2740204 variant in the OXT gene was significantly associated with treatment response (after 1000 permutations p=0.042) and nominally associated with negative symptoms in our sample.
    1 context sentence
    Summary · context
    Therefore, we evaluated if OXT and OXT receptor (OXTR) genes might play a role in the symptom severity and clozapine treatment response in schizophrenia subjects.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03HumanNot a test of Oxytocin aloneObservational studyOther

    In people with schizophrenia, variants in the OXT receptor gene were nominally associated with overall symptom severity on the Brief Psychiatric Rating Scale.

    In plain wordsIn people with schizophrenia, variants in the oxytocin receptor gene were possibly linked to overall symptom severity.

    Peptide
    Oxytocin
    Outcome
    Not applicableOXTR variants and overall symptom severity
    Study

    n: not reported in source

    Outcome group
    Psychiatric symptoms · Mental health and mood

    Source sentences

    Summary
    Furthermore, variants in the OXTR were nominally associated with severity of overall symptoms accessed using the Brief Psychiatric Rating Scale (rs237885, rs237887)
    1 context sentence
    Summary · context
    Therefore, we evaluated if OXT and OXT receptor (OXTR) genes might play a role in the symptom severity and clozapine treatment response in schizophrenia subjects.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04HumanNot a test of Oxytocin aloneObservational studyOther

    In people with schizophrenia, variants in the OXT receptor gene were nominally associated with improvement of positive symptoms.

    In plain wordsIn people with schizophrenia, variants in the oxytocin receptor gene were possibly linked to improvement of positive symptoms.

    Peptide
    Oxytocin
    Outcome
    Not applicableOXTR variants and improvement of positive symptoms
    Study

    n: not reported in source

    Outcome group
    Psychiatric symptoms · Mental health and mood

    Source sentences

    Summary
    as well as on the improvement of the positive symptoms (rs11706648, rs4686301, rs237899).
    1 context sentence
    Summary · context
    Therefore, we evaluated if OXT and OXT receptor (OXTR) genes might play a role in the symptom severity and clozapine treatment response in schizophrenia subjects.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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