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Study · Non-randomized trial · n = 18 · 2010

4 results

Effects of ghrelin, growth hormone-releasing peptide-6, and growth hormone-releasing hormone on growth hormone, adrenocorticotropic hormone, and cortisol release in type 1 diabetes mellitus.

de Sá LB, Nascif SO, Correa-Silva SR, Molica P, Vieira JG, Dib SA, Lengyel AM

Metabolism: clinical and experimental1 Mar 2010Cited by 3 (Europe PMC)

PMID20189610 (opens in a new tab)DOI10.1016/j.metabol.2010.01.021 (opens in a new tab)PepBankPUB-20189610
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with type 1 diabetes and controls, GHRP‑6-induced GH release was lower than ghrelin-induced GH release in both groups.

    In plain wordsIn people with type 1 diabetes and in controls, GHRP‑6 raised growth hormone less than ghrelin did.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH release after GHRP-6 compared with ghrelin
    Study

    n = 18

    Comparator
    Ghrelin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both groups, ghrelin-induced GH release was higher than that after GHRP-6 and GHRH.
    1 context sentence
    Summary · context
    We therefore studied GH, ACTH, and cortisol responses to ghrelin and GHRP-6 in 9 patients with T1DM and 9 control subjects.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with type 1 diabetes, delta AUC of GH after GHRP‑6 did not differ significantly from that in controls.

    In plain wordsIn people with type 1 diabetes, growth hormone release after GHRP‑6 was similar to that in people without diabetes.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH response (delta AUC) to GHRP-6 in type 1 diabetes
    Study

    n = 18

    Comparator
    Healthy controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When analyzing Δ area under the curve (ΔAUC) GH values after ghrelin, GHRP-6, and GHRH, no significant differences were observed in T1DM compared with controls.
    1 context sentence
    Summary · context
    We therefore studied GH, ACTH, and cortisol responses to ghrelin and GHRP-6 in 9 patients with T1DM and 9 control subjects.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with type 1 diabetes, delta AUC of cortisol after GHRP‑6 did not differ significantly from that in controls.

    In plain wordsIn people with type 1 diabetes, cortisol release after GHRP‑6 was similar to that in people without diabetes.

    Peptide
    GHRP-6
    Outcome
    No significant changeCortisol response (delta AUC) to GHRP-6 in type 1 diabetes
    Study

    n = 18

    Comparator
    Healthy controls
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No significant differences were seen in ΔAUC cortisol values in both groups after ghrelin and GHRP-6.
    1 context sentence
    Summary · context
    We therefore studied GH, ACTH, and cortisol responses to ghrelin and GHRP-6 in 9 patients with T1DM and 9 control subjects.
  4. 04HumanNon-randomized trialEfficacy outcome

    In patients with type 1 diabetes, delta AUC of ACTH after GHRP‑6 did not differ from that in controls.

    In plain wordsIn people with type 1 diabetes, ACTH release after GHRP‑6 was similar to that in people without diabetes.

    Peptide
    GHRP-6
    Outcome
    No significant changeACTH response (delta AUC) to GHRP-6 in type 1 diabetes
    Study

    n = 18

    Comparator
    Healthy controls
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No differences were seen in ΔAUC ACTH levels in both groups after ghrelin and GHRP-6.
    1 context sentence
    Summary · context
    We therefore studied GH, ACTH, and cortisol responses to ghrelin and GHRP-6 in 9 patients with T1DM and 9 control subjects.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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