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Study · Animal study (in vivo) · male sprague-dawley rats · 2010

4 results

Effect of intermittent systemic administration of recombinant parathyroid hormone (1-34) on mandibular fracture healing in rats.

Rowshan HH, Parham MA, Baur DA, McEntee RD, Cauley E, Carriere DT, Wood JC, Demsar WJ, Pizarro JM

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons1 Feb 2010Cited by 46 (Europe PMC)

PMID20116693 (opens in a new tab)DOI10.1016/j.joms.2009.09.045 (opens in a new tab)PepBankPUB-20116693
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with mandibular fractures, PTH(1-34) significantly changed callous formation compared with vehicle control, with direction unspecified.

    In plain wordsIn rats with jaw fractures, callous formation differed between PTH(1-34) and control animals. The abstract does not state the direction.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Direction not reportedCallous formation
    Study

    Male Sprague-Dawley ratsn: not reported in source

    Surgically created unilateral mandibular fracture
    Comparator
    Vehicle control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (Male Sprague-Dawley rats).

    Source sentences

    Summary
    The PTH(1-34) treated rats showed a statistically significant difference (P < .05) in callous formation compared with the control animals.
    3 context sentences
    Summary · context
    A controlled unilateral mandibular fracture was created surgically in 29 male Sprague-Dawley rats and then stabilized using an external fixation device.
    Summary · context
    The rats were divided into 2 groups: 1 group received daily subcutaneous injections of 10 microg/kg of PTH(1-34) and 1 group served as the vehicle control.
    Summary · context
    The rats were killed on postoperative days 7 and 21, and radiographic densitometry and histologic evaluation of new bone formation were performed.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with mandibular fractures, radiographic densitometry showed increased injury-site bone density at day 7 in the PTH(1-34) group.

    In plain wordsIn rats with jaw fractures, scans showed increased bone density at the injury site in the PTH group at day 7.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone density at day 7
    Study

    Male Sprague-Dawley ratsn: not reported in source

    Surgically created unilateral mandibular fracture
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 7 daysAs given in this study (Male Sprague-Dawley rats).

    Source sentences

    Summary
    Radiographic densitometry evaluation of the injury site revealed an increase in bone density, apparent at day 7 in the experimental group.
    3 context sentences
    Summary · context
    A controlled unilateral mandibular fracture was created surgically in 29 male Sprague-Dawley rats and then stabilized using an external fixation device.
    Summary · context
    The rats were divided into 2 groups: 1 group received daily subcutaneous injections of 10 microg/kg of PTH(1-34) and 1 group served as the vehicle control.
    Summary · context
    The rats were killed on postoperative days 7 and 21, and radiographic densitometry and histologic evaluation of new bone formation were performed.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with mandibular fractures, histology showed an apparent increase in new bone with PTH(1-34) versus control at 21 days.

    In plain wordsIn rats with jaw fractures, PTH(1-34) appeared to increase new bone compared with control animals.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseNew bone formation at day 21
    Study

    Male Sprague-Dawley ratsn: not reported in source

    Surgically created unilateral mandibular fracture
    Comparator
    Vehicle control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 21 daysAs given in this study (Male Sprague-Dawley rats).

    Source sentences

    Summary
    Visual inspection of the histologic sections stained with Masson's trichrome blue showed an apparent increase in new bone formation at 21 days in the PTH-treated group compared with the control group.
    3 context sentences
    Summary · context
    A controlled unilateral mandibular fracture was created surgically in 29 male Sprague-Dawley rats and then stabilized using an external fixation device.
    Summary · context
    The rats were divided into 2 groups: 1 group received daily subcutaneous injections of 10 microg/kg of PTH(1-34) and 1 group served as the vehicle control.
    Summary · context
    The rats were killed on postoperative days 7 and 21, and radiographic densitometry and histologic evaluation of new bone formation were performed.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with mandibular fractures, radiographic bone density did not differ significantly between PTH(1-34) and control at 21 days.

    In plain wordsIn rats with jaw fractures, bone density did not differ significantly between PTH(1-34) and control animals after 21 days.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBone density at day 21
    Study

    Male Sprague-Dawley ratsn: not reported in source

    Surgically created unilateral mandibular fracture
    Comparator
    Vehicle control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneous · 21 daysAs given in this study (Male Sprague-Dawley rats).

    Source sentences

    Summary
    Long-term administration (21-day period) showed no statistically significant differences between the control and experimental group by radiographic densitometry.
    3 context sentences
    Summary · context
    A controlled unilateral mandibular fracture was created surgically in 29 male Sprague-Dawley rats and then stabilized using an external fixation device.
    Summary · context
    The rats were divided into 2 groups: 1 group received daily subcutaneous injections of 10 microg/kg of PTH(1-34) and 1 group served as the vehicle control.
    Summary · context
    The rats were killed on postoperative days 7 and 21, and radiographic densitometry and histologic evaluation of new bone formation were performed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 4NCT06061354

Teriparatide on Maxillary Sinus Floor Osseointegration

Universidad de Valparaison = 4223 Aug 2023 to est. Dec 2024

Bone Regeneration

Trial pageClinicalTrials.govUpdated 30 Nov 2023

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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