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Study · Animal study (in vivo) · mouse · 2009

3 results

[The original nootropic and neuroprotective drug noopept potentiates the anticonvulsant activity of valproate in mice].

Kravchenko EV, Ponteleeva IV, Trofimov SS, Lapa VI, Ostrovskaia RU, Voronina TA

Eksperimental'naia i klinicheskaia farmakologiia1 Nov 2009

PMID20095393 (opens in a new tab)PepBankPUB-20095393
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, a single Noopept administration did not enhance the convulsant effect of corazole.

    In plain wordsIn mice, a single Noopept administration did not increase corazole-induced convulsions.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeConvulsant effect after single Noopept administration
    Study

    mousen: not reported in source

    Corazole-induced convulsions
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Neither a single administration of noopept (0.5 mg/kg, i.p.) nor its repeated introduction in 10 or 35 days enhanced the convulsant effect of corazole, which is evidence that noopept alone does not possess anticonvulsant properties.
    1 context sentence
    Summary · context
    The influence of the original dipeptide drug noopept, known to possess nootrope, neuroprotector, and anxiolytic properties, on the anticonvulsant activity of the antiepileptic drug valproate has been studied on the model of corazole-induced convulsions in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, repeated Noopept administration did not enhance the convulsant effect of corazole.

    In plain wordsIn mice, repeated Noopept administration did not increase corazole-induced convulsions.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeConvulsant effect after repeated Noopept administration
    Study

    mousen: not reported in source

    Corazole-induced convulsions
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 10 or 35 daysAs given in this study (mouse).

    Source sentences

    Summary
    Neither a single administration of noopept (0.5 mg/kg, i.p.) nor its repeated introduction in 10 or 35 days enhanced the convulsant effect of corazole, which is evidence that noopept alone does not possess anticonvulsant properties.
    1 context sentence
    Summary · context
    The influence of the original dipeptide drug noopept, known to possess nootrope, neuroprotector, and anxiolytic properties, on the anticonvulsant activity of the antiepileptic drug valproate has been studied on the model of corazole-induced convulsions in mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, prolonged preliminary Noopept administration enhanced valproate anticonvulsant activity.

    In plain wordsIn mice, preliminary Noopept increased valproate anticonvulsant activity compared with valproate without preliminary Noopept.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseValproate anticonvulsant activity
    Study

    mousen: not reported in source

    Corazole-induced convulsions
    Comparator
    Valproate without preliminary Noopept
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · five weeksAs given in this study (mouse).

    Source sentences

    Summary
    Prolonged (five weeks) preliminary administration of noopept enhanced the anticonvulsant activity of valproate.
    1 context sentence
    Summary · context
    The influence of the original dipeptide drug noopept, known to possess nootrope, neuroprotector, and anxiolytic properties, on the anticonvulsant activity of the antiepileptic drug valproate has been studied on the model of corazole-induced convulsions in mice.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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