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Study · Animal study (in vivo) · mouse · 2009

3 results

[Effects of nootropic drugs on hippocampal and cortical BDNF levels in mice with different exploratory behavior efficacy].

Firstova IuIu, Dolotov OV, Kondrakhin eA, Dubynina EV, Grivennikov IA, Kovalev GI

Eksperimental'naia i klinicheskaia farmakologiia1 Nov 2009Cited by 2 (Europe PMC)

PMID20095391 (opens in a new tab)PepBankPUB-20095391
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with low exploratory efficacy, subchronic semax raised hippocampal BDNF content to 0.123 pg/microg.

    In plain wordsIn mice with low exploratory efficacy, semax raised the level of the brain growth factor BDNF in the hippocampus.

    Peptide
    Semax
    Outcome
    IncreaseHippocampal BDNF content in low-efficacy mice
    Study

    mousen: not reported in source

    Comparator
    Control group
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated · subchronicAs given in this study (mouse).

    Measurements

    BDNF content
    0.123 pg/microg
    semax, LE mouse hippocampus

    Source sentences

    Summary
    After drug administration, changes in the BDNF level were only observed in the hippocamp of LE mice, where it reached (pg/microg) 0.115 +/- 0.004 (for piracetam); 0.119 +/- 0.006 (for phenotropil); 0.123 +/- 0.007 (for semax); and 0.122 +/- 0.009 (for meclophenoxate).
    1 context sentence
    Summary · context
    The influence of subchronic administration of nootropic drugs (piracetam, phenotropil, meclophenoxate, pantocalcine, semax, nooglutil) on the brain-derived neurotrophic factor (BDNF) content in hippocampal and cortical tissues in mice with different exploratory behavior--high efficacy (HE) against l…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with low exploratory efficacy, semax raised cortical BDNF content to 0.093 pg/microg versus 0.071 pg/microg in controls.

    In plain wordsIn mice with low exploratory efficacy, semax raised BDNF in the cortex compared with the control group.

    Peptide
    Semax
    Outcome
    IncreaseCortical BDNF content in low-efficacy mice
    Study

    mousen: not reported in source

    Comparator
    Control group
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated · subchronicAs given in this study (mouse).

    Measurements

    BDNF content
    0.093 pg/microg
    semax, LE mouse cortex
    BDNF content
    0.071 pg/microg
    control, LE mouse cortex

    Source sentences

    Summary
    In the LE mice cortex, the BDNF content increased only after piracetam and semax injections (to 0.083 +/- 0.003 and 0.093 +/- 0.008, respectively, vs. 0.071 +/- 0.003 pg/microg in the control group; p < 0.0005).
    1 context sentence
    Summary · context
    The influence of subchronic administration of nootropic drugs (piracetam, phenotropil, meclophenoxate, pantocalcine, semax, nooglutil) on the brain-derived neurotrophic factor (BDNF) content in hippocampal and cortical tissues in mice with different exploratory behavior--high efficacy (HE) against l…

Studies that did not test the peptide alone1

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

  1. 03AnimalNot a test of Semax aloneAnimal study (in vivo)Mechanism

    In mice with high exploratory efficacy, the drugs tested together, including semax, did not change cortical BDNF content.

    In plain wordsIn mice with high exploratory efficacy, the tested drugs, including semax, did not change BDNF in the cortex.

    Peptide
    Semax
    Outcome
    No significant changeCortical BDNF content in high-efficacy mice
    Study

    mousen: not reported in source

    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition

    Source sentences

    Summary
    No changes were observed in the cortex of HE mice.
    1 context sentence
    Summary · context
    The influence of subchronic administration of nootropic drugs (piracetam, phenotropil, meclophenoxate, pantocalcine, semax, nooglutil) on the brain-derived neurotrophic factor (BDNF) content in hippocampal and cortical tissues in mice with different exploratory behavior--high efficacy (HE) against l…

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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