In replanted avulsed permanent teeth, soaking in thymosin alpha‑1 and daily gingival injection gave periodontal healing in 77% of teeth versus 14% in the control group at 48 months.
In plain wordsIn people with knocked-out teeth that were replanted, one trial found more periodontal healing at 48 months with thymosin alpha‑1 than with control.
- Peptide
- Thymosin alpha-1
- Outcome
- IncreasePeriodontal healing at 48 months
- Study
n: not reported in source
- Comparator
- Control group
- Outcome group
- Wound healing · Skin and wound
- Studied dose
- Dose not stated · 10-minute soak before replantation, then daily gingival injection · first 7 days after replantationAs given in this study (human).
Measurements
- Periodontal healing
- 77%
- thymosin alpha 1
- Periodontal healing
- 14%
- control
Source sentences
They reported a strong benefit at 48 months (14% with periodontal healing in the control group versus 77% for the experimental group).
1 context sentence(design, population, supporting numbers)
Study two (which had a moderate risk of bias) investigated a 10-minute soaking in thymosin alpha 1 prior to replantation and then its further use as a daily gingival injection for the first 7 days.