Effect of teriparatide [rhPTH(1,34)] and calcitonin on intertransverse process fusion in a rabbit model.

Lehman RA Jr, Dmitriev AE, Cardoso MJ, Helgeson MD, Christensen CL, Raymond JW, Eckel TT, Riew KD

Spine1 Jan 2010Cited by 45 (Europe PMC)

PMID20081509DOI10.1097/brs.0b013e3181b71a96PepBankPUB-20081509

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion, teriparatide increased histologic fusion rates versus autograft control.
In plain wordsIn rabbits after spinal fusion, teriparatide increased histologic fusion rates compared with autograft control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseHistologic fusion rate
Study
New Zealand white rabbitsn: not reported in source
Posterolateral L5-L6 intertransverse process arthrodesis
Comparator
Autograft control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg/day · subcutaneous · 8 weeksAs given in this study (New Zealand white rabbits).
Measurements
Histologic fusion rate
86.7%
teriparatide
Histologic fusion rate
50%
autograft control
Source sentences
Summary
Histologic fusion rates for teriparatide averaged 86.7% and was significantly greater than the autograft control group (50%) (P = 0.033).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-one New Zealand white rabbits underwent a posterolateral L5-L6 intertransverse process arthrodesis using autogenous iliac crest bone graft.
Summary · context
All animals received daily subcutaneous injections of group I (n = 17) 1 mL of saline placebo; group II (n = 17) 10 microg/kg/day of teriparatide; group III (n = 17) 14 IU/animal of calcitonin during the 8-week postoperative period.
Report a problemFND-2008150901
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion, teriparatide showed a nonsignificant trend toward higher radiographic fusion rates than calcitonin.
In plain wordsIn rabbits after spinal fusion, radiographic fusion rates tended to exceed calcitonin rates with teriparatide, but the difference was not significant.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeRadiographic fusion rate
Study
New Zealand white rabbitsn: not reported in source
Posterolateral L5-L6 intertransverse process arthrodesis
Comparator
Calcitonin
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg/day · subcutaneous · 8 weeksAs given in this study (New Zealand white rabbits).
Measurements
Radiographic fusion rate
85.7%
teriparatide
Radiographic fusion rate
56.3%
calcitonin
Source sentences
Summary
Radiographically, there was a strong trend towards teriparatide being superior to the calcitonin group (85.7% vs. 56.3%, respectively; P = 0.07).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-one New Zealand white rabbits underwent a posterolateral L5-L6 intertransverse process arthrodesis using autogenous iliac crest bone graft.
Summary · context
All animals received daily subcutaneous injections of group I (n = 17) 1 mL of saline placebo; group II (n = 17) 10 microg/kg/day of teriparatide; group III (n = 17) 14 IU/animal of calcitonin during the 8-week postoperative period.
Report a problemFND-2008150902
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion, teriparatide increased the Emery histologic score versus autologous graft control.
In plain wordsIn rabbits after spinal fusion, teriparatide increased the histologic score compared with autologous graft control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseEmery histologic score
Study
New Zealand white rabbitsn: not reported in source
Posterolateral L5-L6 intertransverse process arthrodesis
Comparator
Autologous graft control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg/day · subcutaneous · 8 weeksAs given in this study (New Zealand white rabbits).
Measurements
Emery score
6.26 score
teriparatide
Emery score
5.99 score
autologous group
Source sentences
Summary
The average Emery grading score was 5.99 +/- 1.46 SD for the autologous group and 6.26 +/- 0.93 SD for the teriparatide group (P = 0.031).
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-one New Zealand white rabbits underwent a posterolateral L5-L6 intertransverse process arthrodesis using autogenous iliac crest bone graft.
Summary · context
All animals received daily subcutaneous injections of group I (n = 17) 1 mL of saline placebo; group II (n = 17) 10 microg/kg/day of teriparatide; group III (n = 17) 14 IU/animal of calcitonin during the 8-week postoperative period.
Report a problemFND-2008150903
04AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion, teriparatide showed nonsignificantly less flexion and extension motion.
In plain wordsIn rabbits after spinal fusion, teriparatide showed less flexion and extension motion, but the difference was not significant.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeFlexion and extension motion
Study
New Zealand white rabbitsn: not reported in source
Posterolateral L5-L6 intertransverse process arthrodesis
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg/day · subcutaneous · 8 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
Although not significant, the teriparatide group showed less motion in flexion/extension, lateral bending, and axial rotation.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-one New Zealand white rabbits underwent a posterolateral L5-L6 intertransverse process arthrodesis using autogenous iliac crest bone graft.
Summary · context
All animals received daily subcutaneous injections of group I (n = 17) 1 mL of saline placebo; group II (n = 17) 10 microg/kg/day of teriparatide; group III (n = 17) 14 IU/animal of calcitonin during the 8-week postoperative period.
Report a problemFND-2008150904
05AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion, teriparatide showed nonsignificantly less lateral bending motion.
In plain wordsIn rabbits after spinal fusion, teriparatide showed less lateral bending motion, but the difference was not significant.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeLateral bending motion
Study
New Zealand white rabbitsn: not reported in source
Posterolateral L5-L6 intertransverse process arthrodesis
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg/day · subcutaneous · 8 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
Although not significant, the teriparatide group showed less motion in flexion/extension, lateral bending, and axial rotation.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-one New Zealand white rabbits underwent a posterolateral L5-L6 intertransverse process arthrodesis using autogenous iliac crest bone graft.
Summary · context
All animals received daily subcutaneous injections of group I (n = 17) 1 mL of saline placebo; group II (n = 17) 10 microg/kg/day of teriparatide; group III (n = 17) 14 IU/animal of calcitonin during the 8-week postoperative period.
Report a problemFND-2008150905
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion, teriparatide showed nonsignificantly less axial rotation motion.
In plain wordsIn rabbits after spinal fusion, teriparatide showed less axial rotation motion, but the difference was not significant.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeAxial rotation motion
Study
New Zealand white rabbitsn: not reported in source
Posterolateral L5-L6 intertransverse process arthrodesis
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg/day · subcutaneous · 8 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
Although not significant, the teriparatide group showed less motion in flexion/extension, lateral bending, and axial rotation.
2 context sentences(design, population, supporting numbers)
Summary · context
Fifty-one New Zealand white rabbits underwent a posterolateral L5-L6 intertransverse process arthrodesis using autogenous iliac crest bone graft.
Summary · context
All animals received daily subcutaneous injections of group I (n = 17) 1 mL of saline placebo; group II (n = 17) 10 microg/kg/day of teriparatide; group III (n = 17) 14 IU/animal of calcitonin during the 8-week postoperative period.
Report a problemFND-2008150906

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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