Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adults.

Pavlovic D, Pekic S, Stojanovic M, Zivkovic V, Djurovic B, Jovanovic V, Miljic N, Medic-Stojanoska M, Doknic M, Miljic D, Djurovic M, Casanueva F, Popovic V

European journal of neurology30 Dec 2009Cited by 23 (Europe PMC)

PMID20050894DOI10.1111/j.1468-1331.2009.02910.xPepBankPUB-20050894

Publisher page PubMedAsk about this study

Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01HumanNot a test of GHRP-6 aloneObservational studyOther
In adults with TBI assessed using a GHRH plus GHRP‑6 test, GH deficiency or insufficiency occurred in 20 patients (32.8%).
In plain wordsIn adults with brain injury tested with GHRH plus GHRP‑6, 20 patients had deficient or insufficient growth hormone secretion.
Peptide
GHRP-6
Outcome
Not applicableGH deficiency or insufficiency
Study
n = 61
traumatic brain injury
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Patients with GH deficiency or insufficiency
20 patients
TBI cohort
GH deficiency or insufficiency prevalence
32.8%
TBI cohort
Source sentences
Summary
GH deficiency (GHD) and GH insufficiency (GHI) were found in 20 patients (32.8%).
2 context sentences(design, population, supporting numbers)
Summary · context
We performed retrospective and cross-sectional study of endocrine and cognitive function in TBI in 61 patients (aged 37.7 +/- 1.7 years) of both sexes (44 m,17 f), at least 1 year after TBI (3.9 +/- 0.6 years).
Summary · context
Serum insulin-like growth factor 1 (IGF-I), thyroxin, thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (in men), prolactin, and cortisol were measured, and GH secretion was assessed by growth hormone releasing hormone (GHRH) + growth hormo…
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2005089401
02HumanNot a test of GHRP-6 aloneObservational studyOther
In adults with TBI, adjusted neuropsychological test results did not differ by GH status assessed with GHRH plus GHRP‑6.
In plain wordsIn adults with brain injury, cognitive test results did not differ between groups classified by growth hormone testing.
Peptide
GHRP-6
Outcome
No significant changeNeuropsychological test results by GH status
Study
n = 61
traumatic brain injury
Comparator
GH deficiency, GH insufficiency and normal GH secretion
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
After adjustment for confounders [age, body mass index (BMI), education level, time elapsed from TBI], there were no significant differences in results of neuropsychological tests between patients with TBI with GHD, GHI, and normal GH secretion.
2 context sentences(design, population, supporting numbers)
Summary · context
We performed retrospective and cross-sectional study of endocrine and cognitive function in TBI in 61 patients (aged 37.7 +/- 1.7 years) of both sexes (44 m,17 f), at least 1 year after TBI (3.9 +/- 0.6 years).
Summary · context
Serum insulin-like growth factor 1 (IGF-I), thyroxin, thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (in men), prolactin, and cortisol were measured, and GH secretion was assessed by growth hormone releasing hormone (GHRH) + growth hormo…
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2005089402
03HumanNot a test of GHRP-6 aloneObservational studyOther
In adults with TBI, neuropsychological variables did not correlate with peak GH secretion stimulated by GHRH plus GHRP‑6.
In plain wordsIn adults with brain injury, cognitive test results had no link to peak growth hormone after GHRH plus GHRP‑6 testing.
Peptide
GHRP-6
Outcome
No significant changeNeuropsychological variables and stimulated peak GH
Study
n = 61
traumatic brain injury
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
There were no correlations of neuropsychological variables with stimulated peak GH secretion or IGF-I level.
2 context sentences(design, population, supporting numbers)
Summary · context
We performed retrospective and cross-sectional study of endocrine and cognitive function in TBI in 61 patients (aged 37.7 +/- 1.7 years) of both sexes (44 m,17 f), at least 1 year after TBI (3.9 +/- 0.6 years).
Summary · context
Serum insulin-like growth factor 1 (IGF-I), thyroxin, thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (in men), prolactin, and cortisol were measured, and GH secretion was assessed by growth hormone releasing hormone (GHRH) + growth hormo…
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-2005089403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.