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Study · Systematic review · 2010

1 result

The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans.

Macdonald K, Macdonald TM

Harvard review of psychiatry1 Jan 2010Cited by 364 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In a systematic review of human studies, intranasal oxytocin altered social decision making, processing of social stimuli, social behaviors such as eye contact, and social memory.

    In plain wordsA review of human studies found that oxytocin nasal spray changed social decisions, how social cues are processed, eye contact and social memory.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedProsocial effects of intranasal oxytocin
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    After a short discussion of the evolutionary history of the oxytocin system, critical aspects of its peripheral and central physiology, and several salient technical issues surrounding human oxytocin research, a systematic review of studies of the effects of intranasal oxytocin in humans is presented.
    1 context sentence
    Summary · context
    These effects include alterations in social decision making, processing of social stimuli, certain uniquely social behaviors (e.g., eye contact), and social memory.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials2

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

2 trials · 2 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 2NCT06945926

The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery

Zhejiang Universityn = 2271 Jun 2025 to 2 Jun 2026

Cervical Spinal Stenosis · Thoracic Spinal Stenosis · Lumbar Spinal Stenosis · Rotator Cuff Injury · Femoral Head Necrosis · Spinal Trauma · Knee Joint Injury

Trial pageClinicalTrials.govUpdated 20 Aug 2026
CompletedPhase 4Results postedNCT01081249

Effects of Oxytocin on Behavior and Physiology in a Psychotherapy Setting

MacDonald, Kai, M.D.n = 18Dec 2008 to Jul 2012

Behavior · Anxiety

Trial pageClinicalTrials.govUpdated 16 Oct 2014

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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