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Study · Observational study · n = 15 · 2010

5 results

Comparison of pituitary-adrenal responsiveness between insulin tolerance test and growth hormone-releasing peptide-2 test: a pilot study.

Kano T, Sugihara H, Sudo M, Nagao M, Harada T, Ishizaki A, Nakajima Y, Tanimura K, Okajima F, Tamura H, Ishii S, Shibasaki T, Oikawa S

Peptides5 Jan 2010Cited by 8 (Europe PMC)

PMID20045717 (opens in a new tab)DOI10.1016/j.peptides.2009.12.023 (opens in a new tab)PepBankPUB-20045717
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanObservational studyOther

    In 15 patients suspected of hypopituitarism, peak cortisol in the GHRP‑2 test correlated strongly with peak cortisol in ITT (r=0.817; p<0.0001).

    In plain wordsIn patients suspected of pituitary disease, the cortisol peak after GHRP‑2 was strongly linked to the cortisol peak in the insulin test.

    Peptide
    GHRP-2
    Outcome
    Not applicableCorrelation of peak cortisol, GHRP-2 test vs ITT
    Study

    n = 15

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    100mug · intravenousAs given in this study (human).

    Measurements

    Correlation coefficient r
    0.817
    peak cortisol, GHRP-2 test vs ITT

    Source sentences

    Summary
    There was a strong correlation between the peak cortisol in GHRP-2 test and ITT (r=0.817; p<0.0001).
    2 context sentences
    Summary · context
    To assess whether GHRP-2 test could be an alternative to ITT for diagnosing HPA axis failure, both ITT and GHRP-2 test were performed in 15 patients suspected of hypopituitarism.
    Summary · context
    A 100mug dose of GHRP-2 was administered intravenously and plasma ACTH and serum cortisol concentrations were measured.
  2. 02HumanObservational studyOther

    With a peak cortisol cut-off of 13-14 mug/dl, the GHRP‑2 test had 100% specificity for diagnosing HPA axis failure.

    In plain wordsWith a set cortisol cut-off, the GHRP‑2 test correctly identified every patient with normal pituitary-adrenal function in this small study.

    Peptide
    GHRP-2
    Outcome
    Not applicableSpecificity of GHRP-2 test for HPA axis failure
    Study

    n = 15

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    100mug · intravenousAs given in this study (human).

    Measurements

    Specificity
    100%
    cut-off 13-14 mug/dl

    Source sentences

    Summary
    When the cut-off value for the peak cortisol in GHRP-2 test was set to 13-14mug/dl for diagnosing HPA axis failure, the specificity and sensitivity were 100% and 88.9%, respectively.
    2 context sentences
    Summary · context
    To assess whether GHRP-2 test could be an alternative to ITT for diagnosing HPA axis failure, both ITT and GHRP-2 test were performed in 15 patients suspected of hypopituitarism.
    Summary · context
    A 100mug dose of GHRP-2 was administered intravenously and plasma ACTH and serum cortisol concentrations were measured.
  3. 03HumanObservational studyOther

    With a peak cortisol cut-off of 13-14 mug/dl, the GHRP‑2 test had 88.9% sensitivity for diagnosing HPA axis failure.

    In plain wordsWith a set cortisol cut-off, the GHRP‑2 test found most patients whose pituitary-adrenal axis had failed in this small study.

    Peptide
    GHRP-2
    Outcome
    Not applicableSensitivity of GHRP-2 test for HPA axis failure
    Study

    n = 15

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    100mug · intravenousAs given in this study (human).

    Measurements

    Sensitivity
    88.9%
    cut-off 13-14 mug/dl

    Source sentences

    Summary
    When the cut-off value for the peak cortisol in GHRP-2 test was set to 13-14mug/dl for diagnosing HPA axis failure, the specificity and sensitivity were 100% and 88.9%, respectively.
    2 context sentences
    Summary · context
    To assess whether GHRP-2 test could be an alternative to ITT for diagnosing HPA axis failure, both ITT and GHRP-2 test were performed in 15 patients suspected of hypopituitarism.
    Summary · context
    A 100mug dose of GHRP-2 was administered intravenously and plasma ACTH and serum cortisol concentrations were measured.
  4. 04HumanObservational studyOther

    In patients with HPA axis failure by ITT, the median peak cortisol after GHRP‑2 was 11.4 mug/ml.

    In plain wordsIn patients whose pituitary-adrenal axis failed the insulin test, the median peak cortisol after GHRP‑2 was 11.4 mug/ml.

    Peptide
    GHRP-2
    Outcome
    Not applicableMedian peak cortisol in GHRP-2 test, patients with HPA axis failure by ITT
    Study

    n = 9

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    100mug · intravenousAs given in this study (human).

    Measurements

    Median peak cortisol
    11.4 mug/ml
    HPA axis failure by ITT

    Source sentences

    Summary
    Their median peak cortisol in GHRP-2 test was 11.4mug/ml.
    2 context sentences
    Summary · context
    To assess whether GHRP-2 test could be an alternative to ITT for diagnosing HPA axis failure, both ITT and GHRP-2 test were performed in 15 patients suspected of hypopituitarism.
    Summary · context
    A 100mug dose of GHRP-2 was administered intravenously and plasma ACTH and serum cortisol concentrations were measured.
  5. 05HumanObservational studyOther

    In 6 patients with normal HPA axis status by ITT, the median peak cortisol after GHRP‑2 was 21.4 mug/dl, significantly higher than in patients with HPA axis failure (p=0.0032).

    In plain wordsPatients with a normal insulin test had a higher cortisol peak after GHRP‑2 than patients whose pituitary-adrenal axis failed.

    Peptide
    GHRP-2
    Outcome
    Not applicableMedian peak cortisol in GHRP-2 test, patients with normal HPA axis by ITT
    Study

    n = 6

    Comparator
    Patients with HPA axis failure by ITT
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    100mug · intravenousAs given in this study (human).

    Measurements

    Median peak cortisol
    21.4 mug/dl
    normal HPA axis by ITT

    Source sentences

    Summary
    In 6 patients diagnosed as normal HPA axis status by ITT, their median peak cortisol in response to GHRP-2 test was 21.4mug/dl, significantly higher (p=0.0032) than seen in patients diagnosed as HPA axis failure.
    2 context sentences
    Summary · context
    To assess whether GHRP-2 test could be an alternative to ITT for diagnosing HPA axis failure, both ITT and GHRP-2 test were performed in 15 patients suspected of hypopituitarism.
    Summary · context
    A 100mug dose of GHRP-2 was administered intravenously and plasma ACTH and serum cortisol concentrations were measured.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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