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Study · Not a test of the peptide alone · 2010

3 results

Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.

Sunters A, Armstrong VJ, Zaman G, Kypta RM, Kawano Y, Lanyon LE, Price JS

The Journal of biological chemistry30 Dec 2009Cited by 98 (Europe PMC)

PMID20042609 (opens in a new tab)PMCIDPMC2838297 (opens in a new tab)DOI10.1074/jbc.m109.027086 (opens in a new tab)PepBankPUB-20042609
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 01LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In osteoblastic cells, exogenous des-(1-3)IGF-I mimicked strain-induced IGF-I receptor activation.

    In plain wordsIn cells, des-(1-3)IGF-I activated the IGF-I receptor similarly to mechanical strain.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGF-I receptor activation
    Study

    n: not reported in source

    Primary mouse osteoblasts and UMR-106 osteoblast-like cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    The effect of strain on IGF-IR is mimicked by exogenous des-(1-3)IGF-I and is blocked by the IGF-IR inhibitor H1356.
    1 context sentence
    Summary · context
    To elucidate the mechanisms of strain responsiveness in bone cells, we investigated in vitro the responses of primary mouse osteoblasts and UMR-106 osteoblast-like cells to a single period of dynamic strain.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  2. 02LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In osteoblastic cells, ICI 182,780 increased the des-(1-3)IGF-I concentration required to activate the signaling cascade.

    In plain wordsIn cells, an estrogen receptor blocker increased the des-(1-3)IGF-I concentration needed to activate the signaling cascade.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseConcentration required for cascade activation
    Study

    n: not reported in source

    Primary mouse osteoblasts and UMR-106 osteoblast-like cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    The ER blocker ICI 182,780 increases the concentration of des-(1-3)IGF-I necessary to activate this cascade,
    1 context sentence
    Summary · context
    To elucidate the mechanisms of strain responsiveness in bone cells, we investigated in vitro the responses of primary mouse osteoblasts and UMR-106 osteoblast-like cells to a single period of dynamic strain.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  3. 03LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In osteoblastic cells, estrogen inhibited AKT activation induced by des-(1-3)IGF-I.

    In plain wordsIn cells, estrogen reduced AKT activation induced by des-(1-3)IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseDes-IGF-I-induced AKT activation
    Study

    n: not reported in source

    Primary mouse osteoblasts and UMR-106 osteoblast-like cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    whereas estrogen inhibits both basal AKT activity and its activation by des-(1-3)IGF-I.
    1 context sentence
    Summary · context
    To elucidate the mechanisms of strain responsiveness in bone cells, we investigated in vitro the responses of primary mouse osteoblasts and UMR-106 osteoblast-like cells to a single period of dynamic strain.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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