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Study · Measured the body's own peptide · 2010

4 results

Thyroid hormone-induced cardiac mechano growth factor expression depends on beating activity.

van Dijk-Ottens M, Vos IH, Cornelissen PW, de Bruin A, Everts ME

Endocrinology23 Dec 2009Cited by 5 (Europe PMC)

PMID20032059 (opens in a new tab)DOI10.1210/en.2009-0520 (opens in a new tab)PepBankPUB-20032059
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice treated with thyroid hormone for 12 d, MGF mRNA expression increased in the midregions of the septum and left ventricular wall.

    In plain wordsIn mice given thyroid hormone, the body's own MGF increased in parts of the heart wall.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCardiac MGF mRNA expression after thyroid hormone
    Study

    mousen: not reported in source

    Thyroid hormone-treated mice
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    MGF mRNA expression was specifically increased in midregions of the septum and left ventricular wall.
    1 context sentence
    Summary · context
    To investigate the regulation of MGF expression in heart, mice were treated with thyroid hormone (T(3)) for 12 d to induce physiological cardiac hypertrophy.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In hyperthyroid and hypothyroid mouse hearts, MGF expression correlated strongly with increased or decreased beating frequency.

    In plain wordsIn mice, the body's own MGF in the heart followed how fast the heart beat.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableCorrelation of cardiac MGF expression with beating frequency
    Study

    mousen: not reported in source

    Thyroid hormone-treated mice
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Interestingly, MGF expression strongly correlated with the increased or decreased beating frequency of hyperthyroid and hypothyroid hearts.
    1 context sentence
    Summary · context
    To investigate the regulation of MGF expression in heart, mice were treated with thyroid hormone (T(3)) for 12 d to induce physiological cardiac hypertrophy.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In neonatal rat cardiomyocytes, thyroid hormone treatment increased contractile activity and MGF mRNA expression.

    In plain wordsIn rat heart cells, thyroid hormone raised beating rate and the body's own MGF levels.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA in cardiomyocytes after thyroid hormone
    Study

    ratn: not reported in source

    Neonatal rat cardiomyocytes
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Upon T(3) treatment, cardiomyocytes increased both contractile activity measured as beats per minute and MGF as well as IGF-IEa mRNA expression.
    1 context sentence
    Summary · context
    To further investigate the mechanically dependent induction of MGF, neonatal rat cardiomyocytes were isolated and exposed to T(3).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    In neonatal rat cardiomyocytes arrested with KCl, thyroid hormone did not up-regulate MGF, whereas IGF-IEa was still induced.

    In plain wordsIn rat heart cells stopped from beating, thyroid hormone did not raise the body's own MGF.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF mRNA in contractile-arrested cardiomyocytes after thyroid hormone
    Study

    ratn: not reported in source

    Neonatal rat cardiomyocytes arrested with KCl
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Importantly, when cardiomyocytes were contractile arrested by KCl, simultaneous exposure to T(3) prevented the up-regulation of MGF, whereas IGF-IEa was still induced.
    1 context sentence
    Summary · context
    To further investigate the mechanically dependent induction of MGF, neonatal rat cardiomyocytes were isolated and exposed to T(3).

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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