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Study · Animal study (in vivo) · goldfish · 2010

1 result

Relationship between alpha-melanocyte-stimulating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus.

Kojima K, Amiya N, Kamijo M, Kageyama H, Uchiyama M, Shioda S, Matsuda K

General and comparative endocrinology11 Dec 2009Cited by 23 (Europe PMC)

PMID20005228 (opens in a new tab)DOI10.1016/j.ygcen.2009.12.004 (opens in a new tab)PepBankPUB-20005228
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In goldfish, intracerebroventricular melanotan II at 100 pmol/g body weight significantly decreased hypothalamic neuropeptide Y mRNA expression.

    In plain wordsIn goldfish, melanotan II given into the brain lowered the activity of the gene for neuropeptide Y, a hunger signal, in the hypothalamus.

    Peptide
    Melanotan II
    Outcome
    DecreaseHypothalamic NPY mRNA expression
    Study

    goldfishn: not reported in source

    Goldfish hypothalamus
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    100 pmol/g body weight · intracerebroventricularAs given in this study (goldfish).

    Source sentences

    Summary
    ICV injection of melanotan II and NPY induced a significant decrease in the expression levels for NPY and POMC mRNA, respectively.
    1 context sentence
    Summary · context
    We also investigated the effect of ICV injection of melanocortin 4 receptor agonist (melanotan II) at 100 pmol/g body weight (BW), which is enough to suppress food intake, or NPY at 10 pmol/g BW, which is enough to enhance food intake, on expression levels of mRNA for NPY or proopiomelanocortin (POM…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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