Parathyroid hormone PTH(1-34) increases the volume, mineral content, and mechanical properties of regenerated mineralizing tissue after distraction osteogenesis in rabbits.

Aleksyniene R, Thomsen JS, Eckardt H, Bundgaard KG, Lind M, Hvid I

Acta orthopaedica1 Dec 2009Cited by 27 (Europe PMC)

PMID19995322PMCIDPMC2823317DOI10.3109/17453670903350032PepBankPUB-19995322

Summary

Background and purposeParathyroid hormone (PTH) has attracted considerable interest as a bone anabolic agent. Recently, it has been suggested that PTH can also enhance bone repair after fracture and distraction osteogenesis. We analyzed bone density and strength of the newly regenerated mineralized tissue after intermittent treatment with PTH in rabbits, which undergo Haversian bone remodeling similar to that in humans.Methods72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days. The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days. At the end of the study, the rabbits were killed and the bone density was evaluated with DEXA. The mechanical bone strength was determined by use of a 3-point bending test.ResultsIn the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.InterpretationWe found that treatment with PTH during distraction osteogenesis resulted in substantially higher mineralized tissue volume, mineral content, and bending strength. This suggests that treatment with PTH may benefit new bone formation during distraction osteogenesis and could form a basis for clinical application of this therapy in humans.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH for 30 days increased regenerate callus ultimate load by 33% versus saline.
In plain wordsIn rabbits, PTH for 30 days increased callus strength versus saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus ultimate load, 30-day treatment
Study
New Zealand White rabbitsn: not reported in source
Tibial distraction osteogenesis
Comparator
Saline for 30 days
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg/day · injection · 30 daysAs given in this study (New Zealand White rabbits).
Source sentences
Summary
In the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days.
Summary · context
The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days.
Show in the study text Report a problemFND-1999532201
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH for 20 days after saline increased regenerate callus ultimate load by 30% versus saline.
In plain wordsIn rabbits, PTH for 20 days after saline increased callus strength versus saline alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus ultimate load, 20-day treatment
Study
New Zealand White rabbitsn: not reported in source
Tibial distraction osteogenesis
Comparator
Saline for 30 days
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg/day · injection · 20 daysAs given in this study (New Zealand White rabbits).
Source sentences
Summary
In the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days.
Summary · context
The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days.
Show in the study text Report a problemFND-1999532202
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH for 30 days increased absorbed energy by 100% versus saline.
In plain wordsIn rabbits, PTH for 30 days increased absorbed energy versus saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAbsorbed energy, 30-day treatment
Study
New Zealand White rabbitsn: not reported in source
Tibial distraction osteogenesis
Comparator
Saline for 30 days
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg/day · injection · 30 daysAs given in this study (New Zealand White rabbits).
Source sentences
Summary
In the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days.
Summary · context
The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days.
Show in the study text Report a problemFND-1999532203
04AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH for 20 days after saline increased absorbed energy by 65% versus saline.
In plain wordsIn rabbits, PTH for 20 days after saline increased absorbed energy versus saline alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAbsorbed energy, 20-day treatment
Study
New Zealand White rabbitsn: not reported in source
Tibial distraction osteogenesis
Comparator
Saline for 30 days
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg/day · injection · 20 daysAs given in this study (New Zealand White rabbits).
Source sentences
Summary
In the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days.
Summary · context
The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days.
Show in the study text Report a problemFND-1999532204
05AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH for 30 days increased callus BMC by 61% versus saline.
In plain wordsIn rabbits, PTH for 30 days increased bone mineral content versus saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone mineral content, 30-day treatment
Study
New Zealand White rabbitsn: not reported in source
Tibial distraction osteogenesis
Comparator
Saline for 30 days
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg/day · injection · 30 daysAs given in this study (New Zealand White rabbits).
Source sentences
Summary
In the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days.
Summary · context
The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days.
Show in the study text Report a problemFND-1999532205
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH for 20 days after saline increased callus BMC by 60% versus saline.
In plain wordsIn rabbits, PTH for 20 days after saline increased bone mineral content versus saline alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone mineral content, 20-day treatment
Study
New Zealand White rabbitsn: not reported in source
Tibial distraction osteogenesis
Comparator
Saline for 30 days
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg/day · injection · 20 daysAs given in this study (New Zealand White rabbits).
Source sentences
Summary
In the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days.
Summary · context
The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days.
Show in the study text Report a problemFND-1999532206
07AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH for 30 days increased callus tissue volume by 179% versus saline.
In plain wordsIn rabbits, PTH for 30 days increased callus tissue volume versus saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus tissue volume, 30-day treatment
Study
New Zealand White rabbitsn: not reported in source
Tibial distraction osteogenesis
Comparator
Saline for 30 days
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg/day · injection · 30 daysAs given in this study (New Zealand White rabbits).
Source sentences
Summary
In the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days.
Summary · context
The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days.
Show in the study text Report a problemFND-1999532207
08AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, PTH for 20 days after saline increased callus tissue volume by 197% versus saline.
In plain wordsIn rabbits, PTH for 20 days after saline increased callus tissue volume versus saline alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus tissue volume, 20-day treatment
Study
New Zealand White rabbitsn: not reported in source
Tibial distraction osteogenesis
Comparator
Saline for 30 days
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 microg/kg/day · injection · 20 daysAs given in this study (New Zealand White rabbits).
Source sentences
Summary
In the 2 PTH-treated groups the regenerate callus ultimate load was 33% and 30% higher, absorbed energy was 100% and 65% higher, BMC was 61% and 60% higher, and callus tissue volume was 179% and 197% higher than for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
72 New Zealand White rabbits underwent tibial mid-diaphyseal osteotomy and the callus was distracted 1 mm/day for 10 days.
Summary · context
The rabbits were divided into 3 groups, which received injections of PTH 25 microg/kg/day for 30 days, saline for 10 days and PTH 25 microg/kg/day for 20 days, or saline for 30 days.
Show in the study text Report a problemFND-1999532208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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