Skip to content

Study · Animal study (in vivo) · rat · 2010

4 results

Strontium ranelate enhances callus strength more than PTH 1-34 in an osteoporotic rat model of fracture healing.

Habermann B, Kafchitsas K, Olender G, Augat P, Kurth A

Calcified tissue international4 Dec 2009Cited by 63 (Europe PMC)

PMID19960189 (opens in a new tab)DOI10.1007/s00223-009-9317-8 (opens in a new tab)PepBankPUB-19960189
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats with fractures, PTH 1‑34 did not significantly increase callus resistance compared with OVX controls.

    In plain wordsIn ovariectomized rats with fractures, PTH did not significantly increase callus resistance compared with untreated ovariectomized rats.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCallus resistance
    Study

    ratn: not reported in source

    Ovariectomized Sprague Dawley rats with closed diaphyseal fracture
    Comparator
    OVX control rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Only treatment with strontium ranelate led to a significant increase in callus resistance compared to the OVX control rats, whereas both PTH 1-34 and strontium ranelate increased the bone volume/tissue volume ratio of the callus.
    2 context sentences
    Summary · context
    We combined the model of an OVX rat with a closed diaphyseal fracture.
    Summary · context
    Fracture healing in OVX rats after treatment with pharmacological doses of strontium ranelate and PTH 1-34 was compared with OVX and sham-treated control groups. After 28 days, the femur was excised and scanned by micro computed tomography and the callus evaluated, after which biomechanical torsiona…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats with fractures, PTH 1‑34 increased callus bone volume/tissue volume ratio compared with OVX controls.

    In plain wordsIn ovariectomized rats with fractures, PTH increased the callus bone volume fraction compared with untreated ovariectomized rats.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus bone volume fraction
    Study

    ratn: not reported in source

    Ovariectomized Sprague Dawley rats with closed diaphyseal fracture
    Comparator
    OVX control rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Only treatment with strontium ranelate led to a significant increase in callus resistance compared to the OVX control rats, whereas both PTH 1-34 and strontium ranelate increased the bone volume/tissue volume ratio of the callus.
    2 context sentences
    Summary · context
    We combined the model of an OVX rat with a closed diaphyseal fracture.
    Summary · context
    Fracture healing in OVX rats after treatment with pharmacological doses of strontium ranelate and PTH 1-34 was compared with OVX and sham-treated control groups. After 28 days, the femur was excised and scanned by micro computed tomography and the callus evaluated, after which biomechanical torsiona…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats with fractures, PTH 1‑34 increased callus trabecular bone volume above that in sham controls.

    In plain wordsIn ovariectomized rats with fractures, PTH increased callus trabecular bone volume above sham control levels.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular bone volume versus sham
    Study

    ratn: not reported in source

    Ovariectomized Sprague Dawley rats with closed diaphyseal fracture
    Comparator
    Sham-treated controls
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    The PTH 1-34-increased trabecular bone volume within the callus was even higher compared to sham.
    2 context sentences
    Summary · context
    We combined the model of an OVX rat with a closed diaphyseal fracture.
    Summary · context
    Fracture healing in OVX rats after treatment with pharmacological doses of strontium ranelate and PTH 1-34 was compared with OVX and sham-treated control groups. After 28 days, the femur was excised and scanned by micro computed tomography and the callus evaluated, after which biomechanical torsiona…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats with fractures, PTH-associated changes in callus tissue volume were not significant compared with OVX controls.

    In plain wordsIn ovariectomized rats with fractures, PTH did not significantly increase callus tissue volume compared with untreated ovariectomized rats.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCallus tissue volume
    Study

    ratn: not reported in source

    Ovariectomized Sprague Dawley rats with closed diaphyseal fracture
    Comparator
    OVX control rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    As for the callus tissue volume, the increase induced by strontium ranelate was significant, contrary to the changes induced by PTH.
    2 context sentences
    Summary · context
    We combined the model of an OVX rat with a closed diaphyseal fracture.
    Summary · context
    Fracture healing in OVX rats after treatment with pharmacological doses of strontium ranelate and PTH 1-34 was compared with OVX and sham-treated control groups. After 28 days, the femur was excised and scanned by micro computed tomography and the callus evaluated, after which biomechanical torsiona…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.