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Study · In vitro (cells) · 2009

2 results

Growth factors enhance endothelial progenitor cell proliferation under high-glucose conditions.

Li W, Yang SY, Hu ZF, Winslet MC, Wang W, Seifalian AM

Medical science monitor : international medical journal of experimental and clinical research1 Dec 2009Cited by 11 (Europe PMC)

PMID19946224 (opens in a new tab)PepBankPUB-19946224
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In endothelial progenitor cells from healthy volunteers, MGF significantly enhanced proliferation in samples with 11.1 and 25.0 mM glucose.

    In plain wordsIn human progenitor cells in the lab, MGF increased cell growth in high-glucose conditions.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseEPC proliferation in MGF-treated cells at 11.1 and 25.0 mM glucose
    Study

    humann: not reported in source

    Endothelial progenitor cells from healthy volunteers
    Outcome group
    Cell proliferation and differentiation · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Significant enhancement of EPC proliferation was observed in MGF-treated cells supplemented with 11.1 and 25.0 mM glucose.
    2 context sentences
    Summary · context
    The effects of glucose and growth regulators on EPC proliferation were determined with the Alamar Blue and Trypan Blue assays.
    Summary · context
    The effect of glucose supplementation at 2.5, 11.1, and 25.0 mM was examined using cells seeded at densities of 15000, 30000, and 45000 cells/ml.
  2. 02LabIn vitro (cells)Efficacy outcome

    In endothelial progenitor cells from healthy volunteers, the growth factors, MGF included, did not enhance proliferation in samples with 2.5 mM glucose.

    In plain wordsIn human progenitor cells in the lab, MGF did not increase cell growth at low glucose.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeEPC proliferation in MGF-treated cells at 2.5 mM glucose
    Study

    humann: not reported in source

    Endothelial progenitor cells from healthy volunteers
    Outcome group
    Cell proliferation and differentiation · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No enhancement of EPC proliferation by the growth factors was detected in any of the cells supplemented with 2.5 mM glucose.
    2 context sentences
    Summary · context
    The purpose of this study was to investigate the impact of growth regulators, including growth hormone (GH), insulin-like growth factor 1 (IGF-1), and mechano growth factor (MGF), on endothelial progenitor cell (EPC) proliferation at different glucose concentrations.
    Summary · context
    The effect of glucose supplementation at 2.5, 11.1, and 25.0 mM was examined using cells seeded at densities of 15000, 30000, and 45000 cells/ml.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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Publication types

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