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Study · Measured the body's own peptide · 2009

5 results

Vitamin D(3) induces expression of human cathelicidin antimicrobial peptide 18 in newborns.

Misawa Y, Baba A, Ito S, Tanaka M, Shiohara M

International journal of hematology28 Nov 2009Cited by 23 (Europe PMC)

PMID19943126 (opens in a new tab)DOI10.1007/s12185-009-0452-9 (opens in a new tab)PepBankPUB-19943126
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In rickets patients, 4 weeks of oral 1alpha hydroxy vitamin D(3) significantly increased the body's own hCAP18 expression in neutrophils compared with healthy controls without it.

    In plain wordsIn rickets patients, vitamin D raised the body's own hCAP18 level in white blood cells compared with untreated healthy controls.

    Peptide
    LL-37
    Outcome
    IncreasehCAP18 expression in neutrophils after 1alpha(OH)D(3)
    Study

    n: not reported in source

    Comparator
    Age-matched healthy controls without 1alpha(OH)D(3)
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Oral intake of 1alpha hydroxy vitamin D(3) (1alpha(OH)D(3)) in rickets patients for 4 weeks significantly increased hCAP18 expression in neutrophils compared to age-matched healthy controls without 1alpha(OH)D(3), indicating the potential of vitamin D(3) as a regulator of the innate immune response of neonates.
    1 context sentence
    Summary · context
    We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In neonates, expression of the body's own hCAP18 (LL‑37 precursor) in neutrophils was significantly lower than in adults.

    In plain wordsNewborns had lower levels of the body's own hCAP18, the LL‑37 precursor, in white blood cells than adults.

    Peptide
    LL-37
    Outcome
    DecreasehCAP18 expression in neutrophils, neonates versus adults
    Study

    n: not reported in source

    Comparator
    Adults
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The percentage as well as fluorescence intensity ratio of hCAP18 and NGAL expression in neonate neutrophils were significantly lower than in adults.
    1 context sentence
    Summary · context
    We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    Expression of the body's own hCAP18 in monocytes did not differ significantly between neonates and adults.

    In plain wordsNewborns and adults had similar levels of the body's own hCAP18 in monocytes.

    Peptide
    LL-37
    Outcome
    No significant changehCAP18 expression in monocytes, neonates versus adults
    Study

    n: not reported in source

    Comparator
    Adults
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Expression of hCAP18 in monocytes, however, was not significantly different between neonates and adults.
    1 context sentence
    Summary · context
    We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Expression of the body's own hCAP18 increased with age.

    In plain wordsThe body's own hCAP18 level rose as people got older.

    Peptide
    LL-37
    Outcome
    IncreasehCAP18 expression with age
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Both hCAP18 and NGAL expression increased in an age-dependent fashion.
    1 context sentence
    Summary · context
    We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    Plasma concentration of the body's own hCAP18 was not significantly different between neonates and adults.

    In plain wordsNewborns and adults had similar blood levels of the body's own hCAP18.

    Peptide
    LL-37
    Outcome
    No significant changePlasma hCAP18 concentration, neonates versus adults
    Study

    n: not reported in source

    Comparator
    Adults
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Plasma concentration of these peptides measured by enzyme-linked immunosorbent assay was not significantly different between neonates and adults.
    1 context sentence
    Summary · context
    We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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