Study · Animal study (in vivo) · sheep · 2010

1 result

Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes.

Backholer K, Bowden M, Gamber K, Bjørbaek C, Iqbal J, Clarke IJ

Neuroendocrinology18 Nov 2009Cited by 41 (Europe PMC)

PMID19923792PMCIDPMC2857620DOI10.1159/000260060PepBankPUB-19923792

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Summary

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Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In lean ovariectomised ewes, the melanocortin agonist MTII reinstated pulsatile luteinizing hormone secretion, whereas naloxone did not.
In plain wordsIn lean sheep without ovaries, a melanocortin drug restored the normal pulses of luteinizing hormone; naloxone did not.
Peptide
Melanotan II
Outcome
IncreasePulsatile LH secretion
Study
sheepn: not reported in source
Lean ovariectomised (OVX) ewes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
A melanocortin agonist (MTII), but not naloxone treatment, reinstated pulsatile LH secretion in lean OVX ewes.
Report a problemFND-1992379201

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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