Melanocortin activity in the amygdala controls appetite for dietary fat.

Boghossian S, Park M, York DA

American journal of physiology. Regulatory, integrative and comparative physiology18 Nov 2009Cited by 50 (Europe PMC)

PMID19923360DOI10.1152/ajpregu.00591.2009PepBankPUB-19923360

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, MTII injected in the central amygdala dose-dependently inhibited food intake for at least 24 h.
In plain wordsIn rats, MTII injected into the amygdala reduced food intake, with larger doses having a larger effect.
Peptide
Melanotan II
Outcome
DecreaseFood intake
Study
ratn: not reported in source
Sprague-Dawley rats with central amygdala cannulas
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · injection into the central amygdalaAs given in this study (rat).
Source sentences
Summary
Injections of the MC4R agonist melanotan II (MTII) in the CeA had a dose-dependent inhibitory effect on food intake that lasted for at least 24 h.
1 context sentence(design, population, supporting numbers)
Summary · context
Sprague-Dawley rats, fitted with CeA cannulas, were fed either chow, a high-fat (HF) diet, or adapted to a two-choice HF or low-fat (LF) diet.
Report a problemFND-1992336001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, the inhibition of food intake by MTII in the central amygdala was greater in rats fed a high-fat diet.
In plain wordsIn rats, MTII in the amygdala reduced food intake more in rats fed a high-fat diet.
Peptide
Melanotan II
Outcome
DecreaseFood intake inhibition in high-fat diet rats
Study
ratn: not reported in source
Sprague-Dawley rats with central amygdala cannulas
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · injection into the central amygdalaAs given in this study (rat).
Source sentences
Summary
This response was greater in rats fed a HF diet.
2 context sentences(design, population, supporting numbers)
Summary · context
Injections of the MC4R agonist melanotan II (MTII) in the CeA had a dose-dependent inhibitory effect on food intake that lasted for at least 24 h.
Summary · context
Sprague-Dawley rats, fitted with CeA cannulas, were fed either chow, a high-fat (HF) diet, or adapted to a two-choice HF or low-fat (LF) diet.
Report a problemFND-1992336002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats adapted to a two-choice high-fat or low-fat diet, MTII decreased high-fat consumption.
In plain wordsIn rats given a choice, MTII in the amygdala reduced eating of high-fat food.
Peptide
Melanotan II
Outcome
DecreaseHigh-fat food consumption in two-choice diet
Study
ratn: not reported in source
Sprague-Dawley rats with central amygdala cannulas
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · injection into the central amygdalaAs given in this study (rat).
Source sentences
Summary
In rats adapted to a two-choice HF/LF diet, MTII decreased HF consumption but had no effect on LF consumption, resulting in a long-lasting decrease in total calorie intake (-35.5% after 24 h, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Sprague-Dawley rats, fitted with CeA cannulas, were fed either chow, a high-fat (HF) diet, or adapted to a two-choice HF or low-fat (LF) diet.
Report a problemFND-1992336003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats adapted to a two-choice high-fat or low-fat diet, MTII had no effect on low-fat consumption.
In plain wordsIn rats given a choice, MTII in the amygdala did not change eating of low-fat food.
Peptide
Melanotan II
Outcome
No significant changeLow-fat food consumption in two-choice diet
Study
ratn: not reported in source
Sprague-Dawley rats with central amygdala cannulas
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · injection into the central amygdalaAs given in this study (rat).
Source sentences
Summary
In rats adapted to a two-choice HF/LF diet, MTII decreased HF consumption but had no effect on LF consumption, resulting in a long-lasting decrease in total calorie intake (-35.5% after 24 h, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Sprague-Dawley rats, fitted with CeA cannulas, were fed either chow, a high-fat (HF) diet, or adapted to a two-choice HF or low-fat (LF) diet.
Report a problemFND-1992336004
05AnimalAnimal study (in vivo)Efficacy outcome
In rats adapted to a two-choice diet, MTII caused a long-lasting decrease in total calorie intake of 35.5% after 24 h.
In plain wordsIn rats given a choice of diets, MTII in the amygdala lowered total calorie intake for a long time.
Peptide
Melanotan II
Outcome
DecreaseTotal calorie intake at 24 h
Study
ratn: not reported in source
Sprague-Dawley rats with central amygdala cannulas
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · injection into the central amygdalaAs given in this study (rat).
Measurements
Total calorie intake change
−35.5%
24 h
Source sentences
Summary
In rats adapted to a two-choice HF/LF diet, MTII decreased HF consumption but had no effect on LF consumption, resulting in a long-lasting decrease in total calorie intake (-35.5% after 24 h, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Sprague-Dawley rats, fitted with CeA cannulas, were fed either chow, a high-fat (HF) diet, or adapted to a two-choice HF or low-fat (LF) diet.
Report a problemFND-1992336005

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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