Intermittent PTH(1-34) does not increase union rates in open rat femoral fractures and exhibits attenuated anabolic effects compared to closed fractures.

Tägil M, McDonald MM, Morse A, Peacock L, Mikulec K, Amanat N, Godfrey C, Little DG

Bone14 Nov 2009Cited by 55 (Europe PMC)

PMID19922821DOI10.1016/j.bone.2009.11.009PepBankPUB-19922821

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with open fractures, radiological union occurred in 58% with PTH(1-34) versus 52% with saline.
In plain wordsIn rats with open fractures, PTH did not significantly improve overall union despite numerically higher radiological union than saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeOpen fracture radiological union
Study
ratn = 51
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Measurements
Radiological union
58%
PTH
Radiological union
52%
saline
Source sentences
Summary
Radiological union was seen in 13/25 (52%) for saline and 15/26 (58%) with PTH((1-34)).
2 context sentences(design, population, supporting numbers)
Summary · context
In conclusion, intermittent PTH((1-34)) produced significant increases in callus size and strength in closed fractures, but failed to increase the rate of union in an open fracture model.
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282104
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with open fractures, mechanically defined union occurred in 65% with PTH(1-34) versus 63% with saline.
In plain wordsIn rats with open fractures, PTH did not significantly improve mechanical union compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeOpen fracture mechanical union
Study
ratn = 33
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Measurements
Mechanical union
65%
PTH
Mechanical union
63%
saline
Source sentences
Summary
In open fractures the mechanically defined union rate was 10/16 (63%) in saline and 11/17 (65%) in PTH((1-34)) treated fractures.
2 context sentences(design, population, supporting numbers)
Summary · context
In conclusion, intermittent PTH((1-34)) produced significant increases in callus size and strength in closed fractures, but failed to increase the rate of union in an open fracture model.
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282102
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with open fractures, histological union occurred in 50% with PTH(1-34) versus 33% with saline.
In plain wordsIn rats with open fractures, PTH did not significantly improve overall union despite numerically higher histological union than saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeOpen fracture histological union
Study
ratn = 19
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Measurements
Histological union
50%
PTH
Histological union
33%
saline
Source sentences
Summary
By histology, the union rate was 3/9 (33%) with saline and 5/10 (50%) with PTH((1-34)).
2 context sentences(design, population, supporting numbers)
Summary · context
In conclusion, intermittent PTH((1-34)) produced significant increases in callus size and strength in closed fractures, but failed to increase the rate of union in an open fracture model.
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282103
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with closed fractures, union was 100% with both PTH(1-34) and saline at six weeks.
In plain wordsIn rats with closed fractures, all fractures united with either PTH or saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeClosed fracture union
Study
ratn: not reported in source
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Measurements
Union rate
100%
PTH and saline closed fracture groups
Source sentences
Summary
In closed fractures, union by any definition was 100% in both PTH((1-34)) and saline groups at 6 weeks.
1 context sentence(design, population, supporting numbers)
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282101
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with open and closed fractures, PTH(1-34) significantly increased callus bone mineral content compared with saline.
In plain wordsIn rats with either fracture model, PTH increased callus mineral content compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus bone mineral content
Study
ratn: not reported in source
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Source sentences
Summary
PTH((1-34)) treatment in both models led to significant increases in callus BMC and volume as well as trabecular bone volume/total volume (BV/TV), as assessed histologically (p<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282105
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with open and closed fractures, PTH(1-34) significantly increased callus volume compared with saline.
In plain wordsIn rats with either fracture model, PTH increased callus volume compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus volume
Study
ratn: not reported in source
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Source sentences
Summary
PTH((1-34)) treatment in both models led to significant increases in callus BMC and volume as well as trabecular bone volume/total volume (BV/TV), as assessed histologically (p<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282106
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with open and closed fractures, PTH(1-34) significantly increased trabecular bone volume fraction compared with saline.
In plain wordsIn rats with either fracture model, PTH increased trabecular bone volume fraction compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular bone volume fraction
Study
ratn: not reported in source
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Source sentences
Summary
PTH((1-34)) treatment in both models led to significant increases in callus BMC and volume as well as trabecular bone volume/total volume (BV/TV), as assessed histologically (p<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282107
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with closed fractures, PTH(1-34) increased peak torque by 60% compared with saline.
In plain wordsIn rats with closed fractures, PTH increased fracture callus strength compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePeak torque in closed fractures
Study
ratn: not reported in source
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Measurements
Peak torque increase
60%
closed fractures versus saline
Source sentences
Summary
In closed fractures, PTH((1-34)) had a robust effect on callus size and strength, with a 60% increase in peak torque (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282108
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with open fractures that united and could be tested, PTH(1-34) increased peak torque by 49% versus saline.
In plain wordsIn rats whose open fractures united and could be tested, PTH increased fracture strength compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePeak torque in united open fractures
Study
ratn: not reported in source
Male Wistar rats with open or closed femoral fractures
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
50 mug/kg 5 days a week · subcutaneous · 6 weeksAs given in this study (rat).
Measurements
Peak torque increase
49%
united testable open fractures versus saline
Source sentences
Summary
In the open fractures that united and could be tested, PTH((1-34)) treatment also increased peak torque by 49% compared to saline (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
108 male Wistar rats were randomly assigned to undergo standardized closed fractures or open osteotomies with periosteal stripping. 27 rats in each group were treated s.c. with PTH((1-34)) at a dose of 50 mug/kg 5 days a week, the other 27 receiving saline. Specimens were harvested at 6 weeks for me…
Report a problemFND-1992282109

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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