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Study · Measured the body's own peptide · 2009

3 results

Expression and subcellular localization of mechano-growth factor in osteoblasts under mechanical stretch.

Zhang B, Xian C, Luo Y, Wang Y

Science in China. Series C, Life sciences1 Oct 2009Cited by 5 (Europe PMC)

PMID19911128 (opens in a new tab)DOI10.1007/s11427-009-0122-4 (opens in a new tab)PepBankPUB-19911128
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Other

    In osteoblasts, cyclic stretching increased MGF mRNA about 5-fold over basal at 6 h, and it returned to normal by 24 h.

    In plain wordsIn bone-forming cells in the lab, stretching briefly raised the cells' own MGF mRNA, which then returned to normal.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA expression under cyclic stretch
    Study

    n: not reported in source

    Osteoblasts under cyclic stretch
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Measurements

    Peak MGF mRNA
    5 fold over basal
    6 h of cyclic stretch

    Source sentences

    Summary
    Quantitative analysis showed that a cyclic stretching stimulation caused a quick and sharp increase of MGF mRNA and protein expression from a low basal level under no stretch; the mRNA and protein levels respectively peaked in 6 and 12 h to 5 and 5.2 fold over the basal level and returned to normal by 24 h.
    1 context sentence
    Summary · context
    In this study, both the mRNA and protein expression of MGF were detected in stretched osteoblasts.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Other

    In osteoblasts, cyclic stretching increased MGF protein 5.2-fold over basal at 12 h, and it returned to normal by 24 h.

    In plain wordsIn bone-forming cells in the lab, stretching briefly raised the cells' own MGF protein, which then returned to normal.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF protein expression under cyclic stretch
    Study

    n: not reported in source

    Osteoblasts under cyclic stretch
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Measurements

    Peak MGF protein
    5.2 fold over basal
    12 h of cyclic stretch

    Source sentences

    Summary
    Quantitative analysis showed that a cyclic stretching stimulation caused a quick and sharp increase of MGF mRNA and protein expression from a low basal level under no stretch; the mRNA and protein levels respectively peaked in 6 and 12 h to 5 and 5.2 fold over the basal level and returned to normal by 24 h.
    1 context sentence
    Summary · context
    In this study, both the mRNA and protein expression of MGF were detected in stretched osteoblasts.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Other

    In stretched osteoblasts, MGF protein was restricted to the nucleus.

    In plain wordsIn bone-forming cells in the lab, the cells' own MGF protein was found only in the nucleus.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableSubcellular localization of MGF protein
    Study

    n: not reported in source

    Osteoblasts under cyclic stretch
    Outcome group
    Growth hormone and IGF-1 · Musculoskeletal

    Source sentences

    Summary
    The subcellular distribution of MGF protein was revealed by immunofluorescence analysis to be restricted to the nucleus.
    1 context sentence
    Summary · context
    In this study, both the mRNA and protein expression of MGF were detected in stretched osteoblasts.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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