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Study · Animal study (in vivo) · mouse · 2010

6 results

Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model.

Laroui H, Dalmasso G, Nguyen HT, Yan Y, Sitaraman SV, Merlin D

Gastroenterology10 Nov 2009Cited by 172 (Europe PMC)

PMID19909746 (opens in a new tab)DOI10.1053/j.gastro.2009.11.003 (opens in a new tab)PepBankPUB-19909746
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with dextran sodium sulfate colitis, NP-KPV protected against inflammatory and histologic changes compared with DSS alone.

    In plain wordsIn mice with colitis, KPV nanoparticles protected against inflammation and tissue damage compared with mice given only the colitis-inducing agent.

    Peptide
    KPV
    Outcome
    DecreaseInflammatory and histologic parameters in DSS colitis
    Study

    mousen: not reported in source

    Dextran sodium sulfate-induced colitis
    Comparator
    DSS only
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mice given dextran sodium sulfate (DSS) followed by NP-KPV were protected against inflammatory and histologic parameters, compared with mice given only DSS.
    1 context sentence
    Summary · context
    The effect of KPV-loaded NPs on inflammatory parameters was determined in vitro as well as in the dextran sodium sulfate-induced colitis mouse model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    KPV delivered in nanoparticles reached similar therapeutic efficacy to free KPV at a 12,000-fold lower concentration.

    In plain wordsIn this study, KPV in nanoparticles worked about as well as free KPV at a much lower concentration.

    Peptide
    KPV
    Outcome
    No significant changeEfficacy of NP-delivered KPV compared with free KPV
    Study

    n: not reported in source

    Comparator
    KPV in free solution
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By using NPs, KPV can be delivered at a concentration that is 12,000-fold lower than that of KPV in free solution, but with similar therapeutic efficacy.
    1 context sentence
    Summary · context
    The effect of KPV-loaded NPs on inflammatory parameters was determined in vitro as well as in the dextran sodium sulfate-induced colitis mouse model.
  3. 03LabIn vitro (cells)Efficacy outcome

    In Caco2-BBE intestinal cells exposed to lipopolysaccharide, KPV-loaded nanoparticles reduced inflammatory responses more than nanoparticles alone, in a dose-dependent way.

    In plain wordsIn cells, KPV-loaded nanoparticles reduced inflammatory responses more than nanoparticles without KPV, and the effect grew with dose.

    Peptide
    KPV
    Outcome
    DecreaseLPS-induced inflammatory response in Caco2-BBE cells
    Study

    n: not reported in source

    Caco2-BBE cells
    Comparator
    Nanoparticles alone
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inflammatory responses to lipopolysaccharide were reduced in Caco2-BBE (brush border enterocyte) cells exposed to NP-KPV compared with those exposed to NPs alone, in a dose-dependent fashion.
    1 context sentence
    Summary · context
    The effect of KPV-loaded NPs on inflammatory parameters was determined in vitro as well as in the dextran sodium sulfate-induced colitis mouse model.

Studies that did not test the peptide alone3

In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking KPV.

  1. 04LabNot a test of KPV aloneIn vitro (cells)Pharmacokinetics

    Once delivered, the nanoparticles quickly released KPV on or within the closed area of colonocytes.

    In plain wordsIn lab tests, the nanoparticles quickly released KPV close to colon cells.

    Peptide
    KPV
    Outcome
    Not applicableKPV release from nanoparticles near colonocytes
    Study

    n: not reported in source

    Colonocytes
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    Once delivered, NPs quickly released KPV on or within the closed area of colonocytes.
    1 context sentence
    Summary · context
    The effect of KPV-loaded NPs on inflammatory parameters was determined in vitro as well as in the dextran sodium sulfate-induced colitis mouse model.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  2. 05LabNot a test of KPV aloneIn vitro (cells)Safety outcome

    Nanoparticles of 400 nm did not affect cell viability or barrier functions.

    In plain wordsIn cells, the 400 nm nanoparticles did not change cell survival or barrier function.

    Peptide
    KPV
    Outcome
    No significant changeNanoparticle effect on cell viability and barrier function
    Study

    n: not reported in source

    Intestinal cells
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    NPs (400 nm) did not affect cell viability or barrier functions.
    1 context sentence
    Summary · context
    The effect of KPV-loaded NPs on inflammatory parameters was determined in vitro as well as in the dextran sodium sulfate-induced colitis mouse model.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  3. 06LabNot a test of KPV aloneIn vitro (cell-free)Other

    A swelling study showed that the alginate-chitosan hydrogel containing labeled nanoparticles collapsed in the colon.

    In plain wordsIn lab tests, the gel carrying the nanoparticles collapsed in the colon.

    Peptide
    KPV
    Outcome
    Not applicableHydrogel swelling and collapse in the colon
    Study

    n: not reported in source

    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    A swelling degree study showed that alginate-chitosan hydrogel containing dextran-fluorescein isothiocyanate-labeled NPs collapsed in the colon.
    1 context sentence
    Summary · context
    The effect of KPV-loaded NPs on inflammatory parameters was determined in vitro as well as in the dextran sodium sulfate-induced colitis mouse model.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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