Study · Animal study (in vivo) · rodents · 2010
14 resultsSajan MP, Bandyopadhyay G, Miura A, Standaert ML, Nimal S, Longnus SL, Van Obberghen E, Hainault I, Foufelle F, Kahn R, Braun U, Leitges M, Farese RV
American journal of physiology. Endocrinology and metabolism3 Nov 2009Cited by 77 (Europe PMC)
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Text rights: Publisher copyright. Results still quote short attributed sentences.
4 results from studies that gave the peptide. No result from this study comes from people.
In intact rodents, AICAR activated aPKC in muscle.
In plain wordsIn rodents, AICAR activated aPKC in muscle.
rodentsn: not reported in source
Intact rodentsSource sentences
Finally, in intact rodents, AICAR and metformin activated aPKC in muscle, but not in liver, despite activating AMPK in both tissues.
In intact rodents, AICAR did not activate aPKC in liver.
In plain wordsIn rodents, AICAR did not activate aPKC in the liver.
rodentsn: not reported in source
Intact rodentsSource sentences
Finally, in intact rodents, AICAR and metformin activated aPKC in muscle, but not in liver, despite activating AMPK in both tissues.
In intact rodents, AICAR activated AMPK in muscle.
In plain wordsIn rodents, AICAR activated AMPK in muscle.
rodentsn: not reported in source
Intact rodentsSource sentences
Finally, in intact rodents, AICAR and metformin activated aPKC in muscle, but not in liver, despite activating AMPK in both tissues.
In intact rodents, AICAR activated AMPK in liver.
In plain wordsIn rodents, AICAR activated AMPK in the liver.
rodentsn: not reported in source
Intact rodentsSource sentences
Finally, in intact rodents, AICAR and metformin activated aPKC in muscle, but not in liver, despite activating AMPK in both tissues.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).
In mice, muscle-specific aPKC depletion impaired AICAR-stimulated glucose disposal.
In plain wordsIn mice, muscle aPKC gene depletion reduced the glucose disposal response to AICAR.
mousen: not reported in source
Muscle-specific aPKC-depleted miceSource sentences
In mice, muscle-specific aPKC (PKC-lambda) depletion by conditional gene targeting impaired AICAR-stimulated glucose disposal
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In mice, muscle-specific aPKC depletion impaired muscle glucose uptake stimulated by AICAR and metformin.
In plain wordsIn mice, muscle aPKC gene depletion reduced muscle glucose uptake stimulated by AICAR and metformin.
mousen: not reported in source
Muscle-specific aPKC-depleted miceSource sentences
In mice, muscle-specific aPKC (PKC-lambda) depletion by conditional gene targeting impaired AICAR-stimulated glucose disposal and stimulatory effects of both AICAR and metformin on 2-deoxyglucose/glucose uptake in muscle in vivo
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In mice with muscle-specific aPKC depletion, AMPK activation remained unimpaired during AICAR experiments.
In plain wordsIn mice, muscle aPKC gene depletion did not impair AMPK activation during AICAR experiments.
mousen: not reported in source
Muscle-specific aPKC-depleted miceSource sentences
however, AMPK activation was unimpaired.
In mice, muscle-specific aPKC (PKC-lambda) depletion by conditional gene targeting impaired
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In isolated mouse extensor digitorum longus muscle, aPKC depletion impaired AICAR-stimulated deoxyglucose uptake.
In plain wordsIn lab tests on mouse muscle, aPKC gene depletion reduced deoxyglucose uptake stimulated by AICAR.
mousen: not reported in source
Isolated extensor digitorum longus muscle with aPKC depletionSource sentences
and AICAR stimulation of 2-[(3)H]deoxyglucose uptake in isolated extensor digitorum longus muscle;
In mice, muscle-specific aPKC (PKC-lambda) depletion by conditional gene targeting impaired
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In cultured L6 myotubes, AICAR-induced aPKC activation required AMPK activation.
In plain wordsIn cells, AICAR required AMPK activation to activate aPKC.
n: not reported in source
Cultured L6 myotubesSource sentences
Here, in cultured L6 myotubes: AICAR- and metformin-induced activation of AMPK was required for activation of aPKC and ERK;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In cultured L6 myotubes, AICAR-induced ERK activation required AMPK activation.
In plain wordsIn cells, AICAR required AMPK activation to activate ERK.
n: not reported in source
Cultured L6 myotubesSource sentences
Here, in cultured L6 myotubes: AICAR- and metformin-induced activation of AMPK was required for activation of aPKC and ERK;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In cultured L6 myotubes, aPKC activation under AICAR or metformin involved and required PDK1 phosphorylation of Thr410-PKC-zeta.
In plain wordsIn cells, aPKC activation under AICAR or metformin required PDK1 phosphorylation of Thr410-PKC-zeta.
n: not reported in source
Cultured L6 myotubesSource sentences
aPKC activation involved and required phosphoinositide-dependent kinase 1 (PDK1) phosphorylation of Thr410-PKC-zeta;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In cultured L6 myotubes, aPKC Thr410 phosphorylation under AICAR or metformin required MEK1-dependent ERK.
In plain wordsIn cells, aPKC Thr410 phosphorylation under AICAR or metformin required MEK1-dependent ERK.
n: not reported in source
Cultured L6 myotubesSource sentences
aPKC Thr410 phosphorylation and activation also required MEK1-dependent ERK;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In cultured L6 myotubes, aPKC activation under AICAR or metformin required MEK1-dependent ERK.
In plain wordsIn cells, aPKC activation under AICAR or metformin required MEK1-dependent ERK.
n: not reported in source
Cultured L6 myotubesSource sentences
aPKC Thr410 phosphorylation and activation also required MEK1-dependent ERK;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In L6 myotubes, AMPK, PDK1, MEK1 or PKC-zeta disruption inhibited glucose transport effects of AICAR and metformin.
In plain wordsIn cells, disruption of AMPK, PDK1, MEK1 or PKC-zeta reduced glucose transport effects of AICAR and metformin.
n: not reported in source
Cultured L6 myotubesSource sentences
and glucose transport effects of AICAR and metformin were inhibited by expression of dominant-negative AMPK, kinase-inactive PDK1, MEK1 inhibitors, kinase-inactive PKC-zeta, and RNA interference (RNAi)-mediated knockdown of PKC-zeta.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
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