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Study · Animal study (in vivo) · laboratory animals · 2009

6 results

[Antiviral activity of immunomodulator Selank in experimental influenza infection].

Ershov FI, Uchakin PN, Uchakina ON, Mezentseva MV, Alekseeva LA, Miasoedov NF

Voprosy virusologii1 Sept 2009Cited by 4 (Europe PMC)

PMID19882898 (opens in a new tab)PepBankPUB-19882898
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals infected with influenza A (H3N2), survival was highest when selank was given by the prevention scheme.

    In plain wordsIn infected laboratory animals, survival was highest when selank was given before infection rather than by other schemes.

    Peptide
    Selank
    Outcome
    IncreaseSurvival (prevention scheme)
    Study

    laboratory animalsn: not reported in source

    Influenza A/Aichi 2/68 (H3N2) infection
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The in vivo studies also demonstrated that the highest survival of laboratory animals was observed when the agent was administered by the prevention scheme.
    1 context sentence
    Summary · context
    The main objective of this study was to evaluate the antiviral properties of the glyproline Selank in both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In animals infected with influenza A (H3N2), selank induced gene expression of interferon-alpha.

    In plain wordsIn infected laboratory animals, selank increased the activity of the interferon-alpha gene.

    Peptide
    Selank
    Outcome
    IncreaseInterferon-alpha gene expression
    Study

    laboratory animalsn: not reported in source

    Influenza A/Aichi 2/68 (H3N2) infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The use of Selank in vivo induced the gene expression of interferon-alpha (IFN-alpha), without affecting that of interleukin (IL)-4, IL-10, or tumor necrosis factor-alpha (TNF-alpha).
    1 context sentence
    Summary · context
    The main objective of this study was to evaluate the antiviral properties of the glyproline Selank in both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In animals infected with influenza A (H3N2), selank did not affect IL-4 gene expression.

    In plain wordsIn infected laboratory animals, selank did not change the activity of the IL-4 gene.

    Peptide
    Selank
    Outcome
    No significant changeIL-4 gene expression
    Study

    laboratory animalsn: not reported in source

    Influenza A/Aichi 2/68 (H3N2) infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The use of Selank in vivo induced the gene expression of interferon-alpha (IFN-alpha), without affecting that of interleukin (IL)-4, IL-10, or tumor necrosis factor-alpha (TNF-alpha).
    1 context sentence
    Summary · context
    The main objective of this study was to evaluate the antiviral properties of the glyproline Selank in both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In animals infected with influenza A (H3N2), selank did not affect IL-10 gene expression.

    In plain wordsIn infected laboratory animals, selank did not change the activity of the IL-10 gene.

    Peptide
    Selank
    Outcome
    No significant changeIL-10 gene expression
    Study

    laboratory animalsn: not reported in source

    Influenza A/Aichi 2/68 (H3N2) infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The use of Selank in vivo induced the gene expression of interferon-alpha (IFN-alpha), without affecting that of interleukin (IL)-4, IL-10, or tumor necrosis factor-alpha (TNF-alpha).
    1 context sentence
    Summary · context
    The main objective of this study was to evaluate the antiviral properties of the glyproline Selank in both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In animals infected with influenza A (H3N2), selank did not affect TNF-alpha gene expression.

    In plain wordsIn infected laboratory animals, selank did not change the activity of the TNF-alpha gene.

    Peptide
    Selank
    Outcome
    No significant changeTNF-alpha gene expression
    Study

    laboratory animalsn: not reported in source

    Influenza A/Aichi 2/68 (H3N2) infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The use of Selank in vivo induced the gene expression of interferon-alpha (IFN-alpha), without affecting that of interleukin (IL)-4, IL-10, or tumor necrosis factor-alpha (TNF-alpha).
    1 context sentence
    Summary · context
    The main objective of this study was to evaluate the antiviral properties of the glyproline Selank in both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2).
  6. 06LabIn vitro (cells)Activity measurement

    In cell culture, selank added 24 hours before influenza A (H3N2) inoculation completely suppressed viral reproduction.

    In plain wordsIn cells, selank added 24 hours before influenza virus completely stopped the virus from multiplying.

    Peptide
    Selank
    Outcome
    DecreaseViral reproduction (preventive scheme, 24 h before inoculation)
    Study

    n: not reported in source

    Cell culture infected with influenza A/Aichi 2/68 (H3N2)
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selank added to the cell culture 24 hours before inoculation (a preventive use scheme) showed the highest efficiency, by completely suppressing viral reproduction.
    1 context sentence
    Summary · context
    The main objective of this study was to evaluate the antiviral properties of the glyproline Selank in both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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