Skip to content

Study · Measured the body's own peptide · 2010

4 results

Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo.

Heilborn JD, Weber G, Grönberg A, Dieterich C, Ståhle M

Experimental dermatology28 Oct 2009Cited by 40 (Europe PMC)

PMID19878298 (opens in a new tab)DOI10.1111/j.1600-0625.2009.00997.x (opens in a new tab)PepBankPUB-19878298
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialMechanism

    In human skin in vivo, topical calcipotriol further enhanced the upregulation of hCAP18 mRNA after acute injury.

    In plain wordsIn people, a vitamin D skin cream raised the body's own hCAP18/LL‑37 gene activity further in fresh skin wounds.

    Peptide
    LL-37
    Outcome
    IncreasehCAP18 mRNA after acute skin injury
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    In the present study, we demonstrate that the upregulation of hCAP18/LL-37 following acute skin injury is further enhanced, at both hCAP18 mRNA and protein levels, after topical treatment with the vitamin D(3) analogue calcipotriol.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialMechanism

    In human skin in vivo, topical calcipotriol further enhanced the upregulation of hCAP18/LL‑37 protein after acute injury.

    In plain wordsIn people, a vitamin D skin cream raised the body's own hCAP18/LL‑37 protein further in fresh skin wounds.

    Peptide
    LL-37
    Outcome
    IncreasehCAP18/LL-37 protein after acute skin injury
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    In the present study, we demonstrate that the upregulation of hCAP18/LL-37 following acute skin injury is further enhanced, at both hCAP18 mRNA and protein levels, after topical treatment with the vitamin D(3) analogue calcipotriol.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelNon-randomized trialMechanism

    In human chronic ulcers, calcipotriol treatment upregulated hCAP18 mRNA.

    In plain wordsIn people with long-lasting skin ulcers, a vitamin D skin cream raised the body's own hCAP18 gene activity.

    Peptide
    LL-37
    Outcome
    IncreasehCAP18 mRNA in chronic ulcers
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    In chronic ulcers, calcipotriol treatment upregulated hCAP18 mRNA, whereas no consistent upregulation of hCAP18 protein was detected.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelNon-randomized trialMechanism

    In human chronic ulcers, calcipotriol treatment did not give a consistent upregulation of hCAP18 protein.

    In plain wordsIn people with long-lasting skin ulcers, a vitamin D skin cream did not consistently raise the body's own hCAP18 protein.

    Peptide
    LL-37
    Outcome
    No significant changehCAP18 protein in chronic ulcers
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    In chronic ulcers, calcipotriol treatment upregulated hCAP18 mRNA, whereas no consistent upregulation of hCAP18 protein was detected.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.