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Study · Animal study (in vivo) · rat · 2010

5 results

Cerebrolysin attenuates blood-brain barrier and brain pathology following whole body hyperthermia in the rat.

Sharma HS, Zimmermann-Meinzingen S, Sharma A, Johanson CE

Acta neurochirurgica. Supplement1 Jan 2010Cited by 16 (Europe PMC)

PMID19812972 (opens in a new tab)DOI10.1007/978-3-211-98811-4_60 (opens in a new tab)PepBankPUB-19812972
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with whole body hyperthermia, cerebrolysin pretreatment attenuated BBB breakdown in a dose-dependent manner.

    In plain wordsIn rats exposed to heat, cerebrolysin reduced blood-brain barrier breakdown, with effects that depended on dose.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBBB breakdown
    Study

    ratn: not reported in source

    Whole body hyperthermia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2 or 5 mL/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with Cerebrolysin (1, 2 or 5 mL/kg i.v.) 24 h before WBH significantly attenuated breakdown of the BBB or BCSFB and brain edema formation.
    1 context sentence
    Summary · context
    This effect was dose dependent.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with whole body hyperthermia, cerebrolysin pretreatment attenuated blood-CSF barrier breakdown in a dose-dependent manner.

    In plain wordsIn rats exposed to heat, cerebrolysin reduced blood-CSF barrier breakdown, with effects that depended on dose.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBlood-CSF barrier breakdown
    Study

    ratn: not reported in source

    Whole body hyperthermia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2 or 5 mL/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with Cerebrolysin (1, 2 or 5 mL/kg i.v.) 24 h before WBH significantly attenuated breakdown of the BBB or BCSFB and brain edema formation.
    1 context sentence
    Summary · context
    This effect was dose dependent.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with whole body hyperthermia, cerebrolysin pretreatment attenuated brain edema formation in a dose-dependent manner.

    In plain wordsIn rats exposed to heat, cerebrolysin reduced brain swelling, with effects that depended on dose.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain edema
    Study

    ratn: not reported in source

    Whole body hyperthermia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2 or 5 mL/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Pretreatment with Cerebrolysin (1, 2 or 5 mL/kg i.v.) 24 h before WBH significantly attenuated breakdown of the BBB or BCSFB and brain edema formation.
    1 context sentence
    Summary · context
    This effect was dose dependent.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with whole body hyperthermia, cerebrolysin reduced cell injury.

    In plain wordsIn rats exposed to heat, cerebrolysin reduced cell injury.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCell injury
    Study

    ratn: not reported in source

    Whole body hyperthermia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2 or 5 mL/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Interestingly, the cell and tissue injury following WBH in cerebrolysin-treated groups were also considerably reduced.
    1 context sentence
    Summary · context
    Pretreatment with Cerebrolysin (1, 2 or 5 mL/kg i.v.) 24 h before WBH significantly attenuated breakdown of the BBB or BCSFB and brain edema formation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with whole body hyperthermia, cerebrolysin reduced tissue injury.

    In plain wordsIn rats exposed to heat, cerebrolysin reduced tissue injury.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseTissue injury
    Study

    ratn: not reported in source

    Whole body hyperthermia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2 or 5 mL/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Interestingly, the cell and tissue injury following WBH in cerebrolysin-treated groups were also considerably reduced.
    1 context sentence
    Summary · context
    Pretreatment with Cerebrolysin (1, 2 or 5 mL/kg i.v.) 24 h before WBH significantly attenuated breakdown of the BBB or BCSFB and brain edema formation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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